TY - JOUR
T1 - Legionella pneumophila and pneumocystis jirovecii coinfection in an infant treated with adrenocorticotropic hormone for infantile spasm
T2 - Case report and literature review
AU - Musallam, Nadira
AU - Bamberger, Ellen
AU - Srugo, Isaac
AU - Dabbah, Husein
AU - Glikman, Daniel
AU - Zonis, Zeev
AU - Kessel, Aharon
AU - Genizi, Jacob
PY - 2014/2
Y1 - 2014/2
N2 - We describe an 8-month-old infant with infantile spasms treated with adrenocorticotropic hormone (ACTH) who presented with fatal Legionella pneumophila and Pneumocystis jirovecii infection. Emphasis is placed on the ensuing immunosuppression and infectious sequelae of ACTH therapy. Given that ACTH therapy may increase the risk of fatal infection, patients undergoing such treatment should be closely monitored, with particular attention paid to the functioning of the immune system.
AB - We describe an 8-month-old infant with infantile spasms treated with adrenocorticotropic hormone (ACTH) who presented with fatal Legionella pneumophila and Pneumocystis jirovecii infection. Emphasis is placed on the ensuing immunosuppression and infectious sequelae of ACTH therapy. Given that ACTH therapy may increase the risk of fatal infection, patients undergoing such treatment should be closely monitored, with particular attention paid to the functioning of the immune system.
KW - Legionella pneumophila
KW - Pneumocystis jirovecii
KW - adrenocorticotropic hormone
KW - immunosuppression
KW - infantile spasms
UR - http://www.scopus.com/inward/record.url?scp=84892732698&partnerID=8YFLogxK
U2 - 10.1177/0883073813511148
DO - 10.1177/0883073813511148
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C2 - 24309244
AN - SCOPUS:84892732698
SN - 0883-0738
VL - 29
SP - 240
EP - 242
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 2
ER -