Abstract
Nineteen bipolar inpatients in manic episodes and 19 normal control subjects were tested on a two-button task which required turning (swiveling) 180° to collect coin-reinforcers. Significantly more right-handed ( 8 16) manic patients turned left (consistently 16 times to collect reinforcement) than right-handed normal controls ( 1 15), most of whom turned consistently right 16 times. Right-handed manic patients were also significantly slower with both hands on a motor sequencing task (Pin Test) than the normal controls. Left hemi-spatial preference may be linked to asymmetric striatal dopaminergic activity common to all psychoses.
| Original language | English |
|---|---|
| Pages (from-to) | 71-76 |
| Number of pages | 6 |
| Journal | Schizophrenia Research |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1992 |
| Externally published | Yes |
Bibliographical note
Funding Information:The authors thank Donna Gaier and Ruth Roelke for help in patient selection and diagnostic inter- viewing. Thanks also to Jeffrey Cummings, M.D. for thoughtful comments on the manuscript. Supported in part by a DMH-Camarillo State Hospital stipend to N.L., NIMH grant MH 43292 to M.F.G. and MH 30911 to R.P. Liberman.
Funding
The authors thank Donna Gaier and Ruth Roelke for help in patient selection and diagnostic inter- viewing. Thanks also to Jeffrey Cummings, M.D. for thoughtful comments on the manuscript. Supported in part by a DMH-Camarillo State Hospital stipend to N.L., NIMH grant MH 43292 to M.F.G. and MH 30911 to R.P. Liberman.
| Funders | Funder number |
|---|---|
| DMH-Camarillo State Hospital | |
| National Institute of Mental Health | R01MH043292, MH 30911 |
Keywords
- Dopamine
- Hemispheric asymmetry
- Mania
- Rotation
