Left cardiac sympathetic denervation in patients with CASQ2-associated catecholaminergic polymorphic ventricular tachycardia

Background: Left cardiac sympathetic denervation (LCSD) was reported to be effective in patients with intractable ryanodine receptor mutation-associated catecholaminergic polymorphic ventricular tachycardia (CPVT). Objectives: To report our experience with LCSD in calsequestrin (CASQ2) mutation-associated CPVT. Methods: LCSD was performed in three patients with CASQ2 mutation-associated CPVT with symptoms and exerciseinduced ventricular arrhythmia despite high dose beta-blocker. Results: None of them experienced symptoms or exerciseinduced ventricular arrhythmia after LCSD. However, all had recurrence of symptoms and/or exercise-induced ventricular arrhythmia after 6 months (6–18 months). Conclusions: LCSD conferred short-term suppression but less than optimal long-term suppression of exercise-induced ventricular arrhythmia among CASQ2-associated CPVT patients.