Latest developments in the MATRICS process

Philip D. Harvey, Michael Foster Green, Keith H. Nuechterlein

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The Measurement and Treatment Research to Improve Cognition in Schizophrenia Research process has led to several developments in the assessment of cognitive functioning for schizophrenia-treatment studies. The first development was the development of a consensus cognitive battery and a United States Food and Drug Administrationendorsed research design. Since the development of the cognitive battery, interest has been spurred in clinical trials in different countries and the development of co-primary functional outcomes measures for these. The MATRICS Consensus Cognitive Battery has been translated into 11 different languages and is being translated into even more. A study has been completed that compared the usefulness of multiple potential coprimary measures, suggesting that the University of California San Diego Performance-Based skills assessment, version II (UPSA-II) is the most suitable for studies conducted in English. These findings suggest that reliable performancebased measures that are easy to administer and highly correlated with cognitive functioning are now available for use in treatment studies.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalInnovations in Clinical Neuroscience
Issue number6
StatePublished - Jun 2010
Externally publishedYes


  • Cognition
  • Cognitive enhancement
  • Disability
  • Schizophrenia


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