Laser based synthesis of nanofunctionalized particulates for pulmonary based controlled drug delivery applications

R. K. Singh, W. S. Kim, M. Ollinger, V. Craciun, I. Coowantwong, G. Hochhaus, N. Koshizaki

Research output: Contribution to journalConference articlepeer-review

16 Scopus citations

Abstract

There is an urgent need to develop controlled drug release systems for the delivery of drugs via the pulmonary route. A key issue in pulmonary dry delivery systems is to reduce the amount of biodegradable polymers that are added to control the drug release. We have synthesized nanofunctionalized drug particles using the pulsed laser deposition on particles (PLDP) (e.g. budesonide) in an effort to control the architecture and thickness of a nanoscale polymer coating on the drug particles. In vitro studies indicated that the dry half-life release for budesonide can be enhanced from 1.2 to over 60 min by a nanoscale coating on the drug particle. Extensive studies have been conducted to characterize the bonding and composition of the polymer film deposited on drug particles.

Original languageEnglish
Pages (from-to)610-614
Number of pages5
JournalApplied Surface Science
Volume197-198
DOIs
StatePublished - 2002
Externally publishedYes
EventCola 2001 - Tsukuba, Japan
Duration: 1 Oct 20011 Oct 2001

Keywords

  • Biodegradable polymers
  • Drug delivery
  • Particles
  • Pulsed laser deposition

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