Laser based synthesis of nanofunctionalized particulates for pulmonary based controlled drug delivery applications

R. K. Singh; W. S. Kim; M. Ollinger; V. Craciun; I. Coowantwong; G. Hochhaus; N. Koshizaki

doi:10.1016/s0169-4332(02)00408-7

Laser based synthesis of nanofunctionalized particulates for pulmonary based controlled drug delivery applications

R. K. Singh, W. S. Kim, M. Ollinger, V. Craciun, I. Coowantwong, G. Hochhaus, N. Koshizaki

Research output: Contribution to journal › Conference article › peer-review

17 Scopus citations

Abstract

There is an urgent need to develop controlled drug release systems for the delivery of drugs via the pulmonary route. A key issue in pulmonary dry delivery systems is to reduce the amount of biodegradable polymers that are added to control the drug release. We have synthesized nanofunctionalized drug particles using the pulsed laser deposition on particles (PLDP) (e.g. budesonide) in an effort to control the architecture and thickness of a nanoscale polymer coating on the drug particles. In vitro studies indicated that the dry half-life release for budesonide can be enhanced from 1.2 to over 60 min by a nanoscale coating on the drug particle. Extensive studies have been conducted to characterize the bonding and composition of the polymer film deposited on drug particles.

Original language	English
Pages (from-to)	610-614
Number of pages	5
Journal	Applied Surface Science
Volume	197-198
DOIs	https://doi.org/10.1016/s0169-4332(02)00408-7
State	Published - 2002
Externally published	Yes
Event	Cola 2001 - Tsukuba, Japan Duration: 1 Oct 2001 → 1 Oct 2001

Keywords

Biodegradable polymers
Drug delivery
Particles
Pulsed laser deposition

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10.1016/s0169-4332(02)00408-7

Cite this

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title = "Laser based synthesis of nanofunctionalized particulates for pulmonary based controlled drug delivery applications",

abstract = "There is an urgent need to develop controlled drug release systems for the delivery of drugs via the pulmonary route. A key issue in pulmonary dry delivery systems is to reduce the amount of biodegradable polymers that are added to control the drug release. We have synthesized nanofunctionalized drug particles using the pulsed laser deposition on particles (PLDP) (e.g. budesonide) in an effort to control the architecture and thickness of a nanoscale polymer coating on the drug particles. In vitro studies indicated that the dry half-life release for budesonide can be enhanced from 1.2 to over 60 min by a nanoscale coating on the drug particle. Extensive studies have been conducted to characterize the bonding and composition of the polymer film deposited on drug particles.",

keywords = "Biodegradable polymers, Drug delivery, Particles, Pulsed laser deposition",

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doi = "10.1016/s0169-4332(02)00408-7",

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AU - Singh, R. K.

AU - Kim, W. S.

AU - Ollinger, M.

AU - Craciun, V.

AU - Coowantwong, I.

AU - Hochhaus, G.

AU - Koshizaki, N.

PY - 2002

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N2 - There is an urgent need to develop controlled drug release systems for the delivery of drugs via the pulmonary route. A key issue in pulmonary dry delivery systems is to reduce the amount of biodegradable polymers that are added to control the drug release. We have synthesized nanofunctionalized drug particles using the pulsed laser deposition on particles (PLDP) (e.g. budesonide) in an effort to control the architecture and thickness of a nanoscale polymer coating on the drug particles. In vitro studies indicated that the dry half-life release for budesonide can be enhanced from 1.2 to over 60 min by a nanoscale coating on the drug particle. Extensive studies have been conducted to characterize the bonding and composition of the polymer film deposited on drug particles.

AB - There is an urgent need to develop controlled drug release systems for the delivery of drugs via the pulmonary route. A key issue in pulmonary dry delivery systems is to reduce the amount of biodegradable polymers that are added to control the drug release. We have synthesized nanofunctionalized drug particles using the pulsed laser deposition on particles (PLDP) (e.g. budesonide) in an effort to control the architecture and thickness of a nanoscale polymer coating on the drug particles. In vitro studies indicated that the dry half-life release for budesonide can be enhanced from 1.2 to over 60 min by a nanoscale coating on the drug particle. Extensive studies have been conducted to characterize the bonding and composition of the polymer film deposited on drug particles.

KW - Biodegradable polymers

KW - Drug delivery

KW - Particles

KW - Pulsed laser deposition

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JF - Applied Surface Science

T2 - Cola 2001

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Laser based synthesis of nanofunctionalized particulates for pulmonary based controlled drug delivery applications

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Keywords

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