Large scale production of human lymphoblastoid (Namalva) interferon - I. Production of crude interferon

Avshalom Mizrahi, Shaul Reuveny, Abraham Traub, Moshe Minai

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Large scale production of human lymphoblastoid (Namalva) interferon (IF) is described. Cell propagation, in up to 50 1 culture volume, was carried out in a low cost medium by a semi-continuous cultivation method. IF was induced by Sendai virus, testing two induction methods. The yield of crude IF varied in the range of 12 - 100 × 103 IF units.ml-1. A weekly production output of 1 - 5 × 108 units crude IF was obtained.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalBiotechnology Letters
Volume2
Issue number6
DOIs
StatePublished - Jun 1980
Externally publishedYes

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