TY - JOUR
T1 - Large-scale integrated microfluidics for protein modification discovery in quasi-cellular environments
AU - Tzur, Amit
AU - Noach, Meirav
AU - Nevenzal, Hadas
AU - Glick, Yair
AU - Chorni, Evelin
AU - Avrahami, Dorit
AU - Barbiro-Michaely, Efrat
AU - Gerber, Doron
N1 - https://doi.org/10.1096/fasebj.29.1_supplement.884.38
PY - 2015/4/1
Y1 - 2015/4/1
N2 - We introduce a modular microfluidic platform for monitoring multiple post-translational modifications of freshly synthesized protein arrays. The system's potency, specificity and flexibility is demonstrated for tyrosine phosphorylation and ubiquitination in quasi-cellular environments recapitulating human cell stoichiometry. Unlimited by design and protein composition, and relying on minute amounts of biological material and cost-effective technology, this unique approach is applicable for a broad range of basic, biomedical and biomarker research.
AB - We introduce a modular microfluidic platform for monitoring multiple post-translational modifications of freshly synthesized protein arrays. The system's potency, specificity and flexibility is demonstrated for tyrosine phosphorylation and ubiquitination in quasi-cellular environments recapitulating human cell stoichiometry. Unlimited by design and protein composition, and relying on minute amounts of biological material and cost-effective technology, this unique approach is applicable for a broad range of basic, biomedical and biomarker research.
UR - https://www.mendeley.com/catalogue/5c62cff9-caaa-3640-8d64-4a018357dbca/
U2 - 10.1096/fasebj.29.1_supplement.884.38
DO - 10.1096/fasebj.29.1_supplement.884.38
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SN - 0892-6638
VL - 29
SP - 884.38
JO - FASEB Journal
JF - FASEB Journal
IS - S1
ER -