Lack of bcr rearrangement in juvenile chronic myeloid leukemia

Amos Toren, Mathilda Mandel, Ninette Amariglio, Ytzhak Hakim, Frida Brok‐Simoni, Gideon Rechavi, Yoram Neumann, Bracha Ramot

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Juvenile chronic myeloid leukemia (JCML) is an unusual subtype of children's leukemia, characterized by unique clinical presentation. Recent studies revealed several biological features, distinguishing from those observed in adult type chronic myeloid leukemia (ACML). The majority of ACML cases are characterized by the presence of an hybrid bcr‐abl rearranged gene. In an effort to elucidate the molecular basis of this unusual leukemia we looked for bcr rearrangement in six JCML cases. No bcr rearrangement was identified in any of the analyzed samples. Together with previous studies from JCML cases, JCML has a different mechanism of leukomogenesis from ACML.

Original languageEnglish
Pages (from-to)493-495
Number of pages3
JournalMedical and Pediatric Oncology
Issue number6
StatePublished - 1991
Externally publishedYes


  • DNA
  • Epstein‐Barr virus
  • juvenile chronic myeloid leukemia


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