Lack of bcr rearrangement in juvenile chronic myeloid leukemia

Amos Toren; Mathilda Mandel; Ninette Amariglio; Ytzhak Hakim; Frida Brok‐Simoni; Gideon Rechavi; Yoram Neumann; Bracha Ramot

doi:10.1002/mpo.2950190608

Lack of bcr rearrangement in juvenile chronic myeloid leukemia

Amos Toren, Mathilda Mandel, Ninette Amariglio, Ytzhak Hakim, Frida Brok‐Simoni, Gideon Rechavi, Yoram Neumann, Bracha Ramot

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Juvenile chronic myeloid leukemia (JCML) is an unusual subtype of children's leukemia, characterized by unique clinical presentation. Recent studies revealed several biological features, distinguishing from those observed in adult type chronic myeloid leukemia (ACML). The majority of ACML cases are characterized by the presence of an hybrid bcr‐abl rearranged gene. In an effort to elucidate the molecular basis of this unusual leukemia we looked for bcr rearrangement in six JCML cases. No bcr rearrangement was identified in any of the analyzed samples. Together with previous studies from JCML cases, JCML has a different mechanism of leukomogenesis from ACML.

Original language	English
Pages (from-to)	493-495
Number of pages	3
Journal	Medical and Pediatric Oncology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1002/mpo.2950190608
State	Published - 1991
Externally published	Yes

Keywords

DNA
Epstein‐Barr virus
juvenile chronic myeloid leukemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/mpo.2950190608

Cite this

@article{94be04e403b5475c8cfd7ecc75629492,

title = "Lack of bcr rearrangement in juvenile chronic myeloid leukemia",

abstract = "Juvenile chronic myeloid leukemia (JCML) is an unusual subtype of children's leukemia, characterized by unique clinical presentation. Recent studies revealed several biological features, distinguishing from those observed in adult type chronic myeloid leukemia (ACML). The majority of ACML cases are characterized by the presence of an hybrid bcr‐abl rearranged gene. In an effort to elucidate the molecular basis of this unusual leukemia we looked for bcr rearrangement in six JCML cases. No bcr rearrangement was identified in any of the analyzed samples. Together with previous studies from JCML cases, JCML has a different mechanism of leukomogenesis from ACML.",

keywords = "DNA, Epstein‐Barr virus, juvenile chronic myeloid leukemia",

author = "Amos Toren and Mathilda Mandel and Ninette Amariglio and Ytzhak Hakim and Frida Brok‐Simoni and Gideon Rechavi and Yoram Neumann and Bracha Ramot",

year = "1991",

doi = "10.1002/mpo.2950190608",

language = "אנגלית",

volume = "19",

pages = "493--495",

journal = "Medical and Pediatric Oncology",

issn = "0098-1532",

publisher = "Wiley-Liss Inc.",

number = "6",

}

TY - JOUR

T1 - Lack of bcr rearrangement in juvenile chronic myeloid leukemia

AU - Toren, Amos

AU - Mandel, Mathilda

AU - Amariglio, Ninette

AU - Hakim, Ytzhak

AU - Brok‐Simoni, Frida

AU - Rechavi, Gideon

AU - Neumann, Yoram

AU - Ramot, Bracha

PY - 1991

Y1 - 1991

N2 - Juvenile chronic myeloid leukemia (JCML) is an unusual subtype of children's leukemia, characterized by unique clinical presentation. Recent studies revealed several biological features, distinguishing from those observed in adult type chronic myeloid leukemia (ACML). The majority of ACML cases are characterized by the presence of an hybrid bcr‐abl rearranged gene. In an effort to elucidate the molecular basis of this unusual leukemia we looked for bcr rearrangement in six JCML cases. No bcr rearrangement was identified in any of the analyzed samples. Together with previous studies from JCML cases, JCML has a different mechanism of leukomogenesis from ACML.

AB - Juvenile chronic myeloid leukemia (JCML) is an unusual subtype of children's leukemia, characterized by unique clinical presentation. Recent studies revealed several biological features, distinguishing from those observed in adult type chronic myeloid leukemia (ACML). The majority of ACML cases are characterized by the presence of an hybrid bcr‐abl rearranged gene. In an effort to elucidate the molecular basis of this unusual leukemia we looked for bcr rearrangement in six JCML cases. No bcr rearrangement was identified in any of the analyzed samples. Together with previous studies from JCML cases, JCML has a different mechanism of leukomogenesis from ACML.

KW - DNA

KW - Epstein‐Barr virus

KW - juvenile chronic myeloid leukemia

UR - http://www.scopus.com/inward/record.url?scp=0026320479&partnerID=8YFLogxK

U2 - 10.1002/mpo.2950190608

DO - 10.1002/mpo.2950190608

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 1683680

AN - SCOPUS:0026320479

SN - 0098-1532

VL - 19

SP - 493

EP - 495

JO - Medical and Pediatric Oncology

JF - Medical and Pediatric Oncology

IS - 6

ER -

Lack of bcr rearrangement in juvenile chronic myeloid leukemia

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this