Lack of association between suicide attempt and a polymorphism at the dopamine receptor D4 locus

M. L. Persson; T. Geijer; D. Wasserman; R. Rockah; A. Frisch; E. Michaelovsky; E. G. Jonsson; A. Apter; A. Weizman

doi:10.1097/00041444-199906000-00008

Lack of association between suicide attempt and a polymorphism at the dopamine receptor D4 locus

M. L. Persson
, T. Geijer
, D. Wasserman
, R. Rockah
, A. Frisch
, E. Michaelovsky
, E. G. Jonsson
, A. Apter
, A. Weizman

Dept. of Public Health Sciences
Karolinska Institutet
Tel Aviv University

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Dopaminergic neurotransmission has been implicated in suicidal behaviour. The 48 bp-repeat polymorphism in the gene coding for dopamine receptor D4 was investigated in a sample of suicide attempters (n = 165) and healthy control subjects (n = 99). No association between suicide attempts and this polymorphism was observed. Neither did any significant differences emerge in comparison with control subjects when the suicide attempters were grouped into different diagnostic categories: unipolar (n = 45), anxiety (n = 23), adjustment (n = 37) and personality disorders, cluster B (n = 36). The results suggest that alleles defined by the investigated polymorphism do not have a major impact on suicidal behaviour.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Psychiatric Genetics
Volume	9
Issue number	2
DOIs	https://doi.org/10.1097/00041444-199906000-00008
State	Published - Jun 1999
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adjustment disorders
Anxiety disorders
Association study
Dopamine receptor D4
Genetics
Personality disorders
Suicidal behaviour
Unipolar disorders

Access to Document

10.1097/00041444-199906000-00008

Cite this

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title = "Lack of association between suicide attempt and a polymorphism at the dopamine receptor D4 locus",

abstract = "Dopaminergic neurotransmission has been implicated in suicidal behaviour. The 48 bp-repeat polymorphism in the gene coding for dopamine receptor D4 was investigated in a sample of suicide attempters (n = 165) and healthy control subjects (n = 99). No association between suicide attempts and this polymorphism was observed. Neither did any significant differences emerge in comparison with control subjects when the suicide attempters were grouped into different diagnostic categories: unipolar (n = 45), anxiety (n = 23), adjustment (n = 37) and personality disorders, cluster B (n = 36). The results suggest that alleles defined by the investigated polymorphism do not have a major impact on suicidal behaviour.",

keywords = "Adjustment disorders, Anxiety disorders, Association study, Dopamine receptor D4, Genetics, Personality disorders, Suicidal behaviour, Unipolar disorders",

author = "Persson, \{M. L.\} and T. Geijer and D. Wasserman and R. Rockah and A. Frisch and E. Michaelovsky and Jonsson, \{E. G.\} and A. Apter and A. Weizman",

year = "1999",

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AU - Persson, M. L.

AU - Geijer, T.

AU - Wasserman, D.

AU - Rockah, R.

AU - Frisch, A.

AU - Michaelovsky, E.

AU - Jonsson, E. G.

AU - Apter, A.

AU - Weizman, A.

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N2 - Dopaminergic neurotransmission has been implicated in suicidal behaviour. The 48 bp-repeat polymorphism in the gene coding for dopamine receptor D4 was investigated in a sample of suicide attempters (n = 165) and healthy control subjects (n = 99). No association between suicide attempts and this polymorphism was observed. Neither did any significant differences emerge in comparison with control subjects when the suicide attempters were grouped into different diagnostic categories: unipolar (n = 45), anxiety (n = 23), adjustment (n = 37) and personality disorders, cluster B (n = 36). The results suggest that alleles defined by the investigated polymorphism do not have a major impact on suicidal behaviour.

AB - Dopaminergic neurotransmission has been implicated in suicidal behaviour. The 48 bp-repeat polymorphism in the gene coding for dopamine receptor D4 was investigated in a sample of suicide attempters (n = 165) and healthy control subjects (n = 99). No association between suicide attempts and this polymorphism was observed. Neither did any significant differences emerge in comparison with control subjects when the suicide attempters were grouped into different diagnostic categories: unipolar (n = 45), anxiety (n = 23), adjustment (n = 37) and personality disorders, cluster B (n = 36). The results suggest that alleles defined by the investigated polymorphism do not have a major impact on suicidal behaviour.

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KW - Anxiety disorders

KW - Association study

KW - Dopamine receptor D4

KW - Genetics

KW - Personality disorders

KW - Suicidal behaviour

KW - Unipolar disorders

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Lack of association between suicide attempt and a polymorphism at the dopamine receptor D4 locus

Abstract

UN SDGs

Keywords

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