Lack of association between suicide attempt and a polymorphism at the dopamine receptor D4 locus

M. L. Persson, T. Geijer, D. Wasserman, R. Rockah, A. Frisch, E. Michaelovsky, E. G. Jonsson, A. Apter, A. Weizman

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20 Scopus citations

Abstract

Dopaminergic neurotransmission has been implicated in suicidal behaviour. The 48 bp-repeat polymorphism in the gene coding for dopamine receptor D4 was investigated in a sample of suicide attempters (n = 165) and healthy control subjects (n = 99). No association between suicide attempts and this polymorphism was observed. Neither did any significant differences emerge in comparison with control subjects when the suicide attempters were grouped into different diagnostic categories: unipolar (n = 45), anxiety (n = 23), adjustment (n = 37) and personality disorders, cluster B (n = 36). The results suggest that alleles defined by the investigated polymorphism do not have a major impact on suicidal behaviour.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalPsychiatric Genetics
Volume9
Issue number2
DOIs
StatePublished - Jun 1999
Externally publishedYes

Keywords

  • Adjustment disorders
  • Anxiety disorders
  • Association study
  • Dopamine receptor D4
  • Genetics
  • Personality disorders
  • Suicidal behaviour
  • Unipolar disorders

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