Abstract
Dopaminergic neurotransmission has been implicated in suicidal behaviour. The 48 bp-repeat polymorphism in the gene coding for dopamine receptor D4 was investigated in a sample of suicide attempters (n = 165) and healthy control subjects (n = 99). No association between suicide attempts and this polymorphism was observed. Neither did any significant differences emerge in comparison with control subjects when the suicide attempters were grouped into different diagnostic categories: unipolar (n = 45), anxiety (n = 23), adjustment (n = 37) and personality disorders, cluster B (n = 36). The results suggest that alleles defined by the investigated polymorphism do not have a major impact on suicidal behaviour.
Original language | English |
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Pages (from-to) | 97-100 |
Number of pages | 4 |
Journal | Psychiatric Genetics |
Volume | 9 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1999 |
Externally published | Yes |
Keywords
- Adjustment disorders
- Anxiety disorders
- Association study
- Dopamine receptor D4
- Genetics
- Personality disorders
- Suicidal behaviour
- Unipolar disorders