TY - JOUR
T1 - L-lactate promotes adult hippocampal neurogenesis
AU - Lev-Vachnish, Yaeli
AU - Cadury, Sharon
AU - Rotter-Maskowitz, Aviva
AU - Feldman, Noa
AU - Roichman, Asael
AU - Illouz, Tomer
AU - Varvak, Alexander
AU - Nicola, Raneen
AU - Madar, Ravit
AU - Okun, Eitan
N1 - Publisher Copyright:
© 2019 Lev-Vachnish, Cadury, Rotter-Maskowitz, Feldman, Roichman, Illouz, Varvak, Nicola, Madar and Okun.
PY - 2019
Y1 - 2019
N2 - Neurogenesis, the formation of new neurons in the adult brain, is important for memory formation and extinction. One of the most studied external interventions that affect the rate of adult neurogenesis is physical exercise. Physical exercise promotes adult neurogenesis via several factors including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF). Here, we identified L-lactate, a physical exercise-induced metabolite, as a factor that promotes adult hippocampal neurogenesis. While prolonged exposure to L-lactate promoted neurogenesis, no beneficial effect was exerted on cognitive learning and memory. Systemic pharmacological blocking of monocarboxylate transporter 2 (MCT2), which transports L-lactate to the brain, prevented lactate-induced neurogenesis, while 3,5-dihydroxybenzoic acid (3,5-DHBA), an agonist for the lactate-receptor hydroxycarboxylic acid receptor 1 (HCAR1), did not affect adult neurogenesis. These data suggest that L-lactate partially mediates the effect of physical exercise on adult neurogenesis, but not cognition, in a MCT2-dependent manner.
AB - Neurogenesis, the formation of new neurons in the adult brain, is important for memory formation and extinction. One of the most studied external interventions that affect the rate of adult neurogenesis is physical exercise. Physical exercise promotes adult neurogenesis via several factors including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF). Here, we identified L-lactate, a physical exercise-induced metabolite, as a factor that promotes adult hippocampal neurogenesis. While prolonged exposure to L-lactate promoted neurogenesis, no beneficial effect was exerted on cognitive learning and memory. Systemic pharmacological blocking of monocarboxylate transporter 2 (MCT2), which transports L-lactate to the brain, prevented lactate-induced neurogenesis, while 3,5-dihydroxybenzoic acid (3,5-DHBA), an agonist for the lactate-receptor hydroxycarboxylic acid receptor 1 (HCAR1), did not affect adult neurogenesis. These data suggest that L-lactate partially mediates the effect of physical exercise on adult neurogenesis, but not cognition, in a MCT2-dependent manner.
KW - Hippocampus
KW - L-lactate
KW - Mct2
KW - Neurogenesis
KW - Neuronal progenitor cells
UR - http://www.scopus.com/inward/record.url?scp=85068538885&partnerID=8YFLogxK
U2 - 10.3389/fnins.2019.00403
DO - 10.3389/fnins.2019.00403
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C2 - 31178678
SN - 1662-4548
VL - 13
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
IS - MAY
M1 - 403
ER -