L-DOPA improves visuo-motor coordination in stable Parkinson's disease patients

S. Hocherman, L. Alexandrovsky, S. Badarny, S. Honigman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The visuo-motor coordination of 26 stable, treated, Parkinson's disease (PD) patients with average Hoehn and Yahr rating of 1.75 ± 0.6, was assessed by use of several tracing and tracking tests before and 30 min after ingestion of the mid-day levodopa (L-DOPA) dose. Significant improvement was found in all aspects of visuo-motor coordination 30 min after drug intake. This included the ability to control the direction and velocity of hand- movement, and the capacity to persist in tracking. A subgroup of 12 patients was tested 30 min and 1 h after L-DOPA intake. A continuing (but small) improvement in directional and velocity control could still be seen an hour after drug intake, while tracking persistence remained unchanged with respect to the preceding test. We conclude that changes in executional capabilities can be documented in 'stable' PD patients, consequent to L-DOPA intake, when high-level skills, such as visuo-motor coordination, are tested.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalParkinsonism and Related Disorders
Volume4
Issue number3
DOIs
StatePublished - Oct 1998
Externally publishedYes

Keywords

  • Levodopa
  • Parkinsonism
  • Visuo-motor control
  • Wearing-off

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