Kinetic modeling of na_v1.7 provides insight into erythromelalgia-associated F1449V mutation

Keyphrases

• Nav1.7 100%
• Kinetic Model 100%
• Erythromelalgia 100%
• Markov Model 66%
• Inactivated State 66%
• Occupancy 33%
• Channel Pore 33%
• Sensory Neurons 33%
• Equivalent State 33%
• Open State 33%
• Voltage-gated Sodium Channel 1.7 33%
• Patch-clamp Recording 33%
• Closed State 33%
• Action Potential Firing 33%
• Channel Function 33%
• Activation Gate 33%
• Stochastic Search 33%
• Hyperpolarized 33%
• Action Potential Threshold 33%
• Firing Threshold 33%
• Transmembrane Helix 33%
• Action Potential 33%
• Pain Disorder 33%
• Channel Protein 33%
• Gain-of-function mutation 33%
• Firing Pattern 33%
• State-making 33%
• Best Model 33%
• Human Embryonic Kidney Cells 33%
• Point mutation 33%
• Intra-protein Interactions 33%
• Inherited Pain Syndromes 33%

Medicine and Dentistry

• Erythromelalgia 100%
• Action Potential 100%
• Pain 50%
• Helix 50%
• Channel Protein 50%
• Point Mutation 50%
• Gain of Function Mutation 50%
• Psychogenic Pain 50%
• Sodium Channel Nav1.7 50%
• Whole Cell 50%
• Kidney Cell 50%
• Patch Clamp 50%

Biochemistry, Genetics and Molecular Biology

• Wild Type 100%
• Nav1.7 100%
• Erythromelalgia 100%
• Action Potential 50%
• Kinetics 25%
• Channel Protein 25%
• Point Mutation 25%
• Gain of Function Mutation 25%
• Whole Cell Patch Clamp 25%
• Sensory Neuron 25%
• Electric Potential 25%
• Sodium Channel 25%
• Patch Clamp Technique 25%