TY - JOUR
T1 - Keeping IPMNs in Check
T2 - A Novel Role for the Transcription Factor NKX6-2 in Preserving an Indolent Cell Identity in Pancreatic Cystic Lesions
AU - Ben-Shmuel, Aviad
AU - Scherz-Shouval, Ruth
N1 - Publisher Copyright:
© 2023 American Association for Cancer Research.
PY - 2023/8/4
Y1 - 2023/8/4
N2 - Summary: In this issue of Cancer Discovery, Sans and colleagues identify the transcription factor NKX6-2 as a principal element in maintaining the low-grade gastric cell phenotype of intraductal papillary mucinous neo-plasms (IPMN) in the pancreas. Their discoveries in patient cohorts and dissection in animal models provide a novel molecular understanding underpinning IPMN differentiation, with implications for risk stratification and therapeutic intervention in pancreatic cancer.
AB - Summary: In this issue of Cancer Discovery, Sans and colleagues identify the transcription factor NKX6-2 as a principal element in maintaining the low-grade gastric cell phenotype of intraductal papillary mucinous neo-plasms (IPMN) in the pancreas. Their discoveries in patient cohorts and dissection in animal models provide a novel molecular understanding underpinning IPMN differentiation, with implications for risk stratification and therapeutic intervention in pancreatic cancer.
UR - http://www.scopus.com/inward/record.url?scp=85166551492&partnerID=8YFLogxK
U2 - 10.1158/2159-8290.cd-23-0590
DO - 10.1158/2159-8290.cd-23-0590
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 37539476
AN - SCOPUS:85166551492
SN - 2159-8274
VL - 13
SP - 1768
EP - 1770
JO - Cancer Discovery
JF - Cancer Discovery
IS - 8
ER -
