Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue

Ronit Sarid; Takaaki Sato; Roy A. Bohenzky; James J. Russo; Yuan Chang

doi:10.1038/nm0397-293

Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue

Ronit Sarid, Takaaki Sato, Roy A. Bohenzky, James J. Russo, Yuan Chang

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306 Scopus citations

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is a newly discovered herpesvirus etiologically associated with Kaposi's sarcoma (KS) and two lymphoproliferative disorders. We describe a KSHV vbcl-2 gene with homology to the proto-oncogene bcl-2. It is expressed in KS lesions and in cell lines derived from primary effusion lymphomas. Using yeast and human cells we demonstrate the ability of KSHV vBcl-2 protein to suppress Bax toxicity. We show that KSHV vBcl-2 heterodimerizes with human Bcl-2 in a yeast two-hybrid system. These results suggest that KSHV vBcl-2 plays an anti-apoptotic role in virus infected cells.

Original language	English
Pages (from-to)	293-298
Number of pages	6
Journal	Nature Medicine
Volume	3
Issue number	3
DOIs	https://doi.org/10.1038/nm0397-293
State	Published - 1997
Externally published	Yes

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abstract = "Kaposi's sarcoma-associated herpesvirus (KSHV) is a newly discovered herpesvirus etiologically associated with Kaposi's sarcoma (KS) and two lymphoproliferative disorders. We describe a KSHV vbcl-2 gene with homology to the proto-oncogene bcl-2. It is expressed in KS lesions and in cell lines derived from primary effusion lymphomas. Using yeast and human cells we demonstrate the ability of KSHV vBcl-2 protein to suppress Bax toxicity. We show that KSHV vBcl-2 heterodimerizes with human Bcl-2 in a yeast two-hybrid system. These results suggest that KSHV vBcl-2 plays an anti-apoptotic role in virus infected cells.",

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AU - Sarid, Ronit

AU - Sato, Takaaki

AU - Bohenzky, Roy A.

AU - Russo, James J.

AU - Chang, Yuan

PY - 1997

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AB - Kaposi's sarcoma-associated herpesvirus (KSHV) is a newly discovered herpesvirus etiologically associated with Kaposi's sarcoma (KS) and two lymphoproliferative disorders. We describe a KSHV vbcl-2 gene with homology to the proto-oncogene bcl-2. It is expressed in KS lesions and in cell lines derived from primary effusion lymphomas. Using yeast and human cells we demonstrate the ability of KSHV vBcl-2 protein to suppress Bax toxicity. We show that KSHV vBcl-2 heterodimerizes with human Bcl-2 in a yeast two-hybrid system. These results suggest that KSHV vBcl-2 plays an anti-apoptotic role in virus infected cells.

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Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue

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