Juvenile rheumatoid arthritis in children with diabetes mellitus

Mary C.J. Rudolf; Myron Genel; William V. Tamborlane; John M. Dwyer

doi:10.1016/S0022-3476(81)80246-6

Juvenile rheumatoid arthritis in children with diabetes mellitus

Mary C.J. Rudolf, Myron Genel, William V. Tamborlane, John M. Dwyer

Yale University

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Seven children with insulin-dependent diabetes mellitus were found to have juvenile rheumatoid arthritis;six of these children had the polyarticular form of the disease. All six had positive serology (rheumatoid factor and/or antinuclear antibody) and clinical or serologic evidence of autoimmune diseases usually ascribed to the thyrogastric cluster. Five expressed HLA antigens associated with increased risk for both diabetes and rheumatoid arthritis in adults. Evidence of B cell hyperactivity and impaired T cell response was found in some, but immunoregulatory, function was normal in all. The association of these two diseases may be the result of factors other than chance alone, and may be more common than previously suspected.

Original language	English
Pages (from-to)	519-524
Number of pages	6
Journal	Journal of Pediatrics
Volume	99
Issue number	4
DOIs	https://doi.org/10.1016/S0022-3476(81)80246-6
State	Published - Oct 1981
Externally published	Yes

Bibliographical note

Funding Information:
From the Departments of Pediatrics and Internal Medicine, Yale University School of Medicine. Supported in part by a grant (A1 11785) to Dr. Dwyer from the National Institutes of Health; clinical studies were performed in the Children's Clinical Research Center, supported by a grant (RR-125) from the General Clinical Research Centers Program, Division of Research Resources, National Institutes of Health. *Reprint address: Department of Pediatrics, Yale University School of Medicine, P. O. Box3333, New Haven, CT 06510. **Recipient of a Clinical Investigator A ward, AM 60021, from the National Institutes of Health. ***Investigator for the Howard Hughes Medical Institute.

Funding

From the Departments of Pediatrics and Internal Medicine, Yale University School of Medicine. Supported in part by a grant (A1 11785) to Dr. Dwyer from the National Institutes of Health; clinical studies were performed in the Children's Clinical Research Center, supported by a grant (RR-125) from the General Clinical Research Centers Program, Division of Research Resources, National Institutes of Health. *Reprint address: Department of Pediatrics, Yale University School of Medicine, P. O. Box3333, New Haven, CT 06510. **Recipient of a Clinical Investigator A ward, AM 60021, from the National Institutes of Health. ***Investigator for the Howard Hughes Medical Institute.

Funders	Funder number
Division of Research Resources
National Institutes of Health	RR-125

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10.1016/S0022-3476(81)80246-6

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title = "Juvenile rheumatoid arthritis in children with diabetes mellitus",

abstract = "Seven children with insulin-dependent diabetes mellitus were found to have juvenile rheumatoid arthritis;six of these children had the polyarticular form of the disease. All six had positive serology (rheumatoid factor and/or antinuclear antibody) and clinical or serologic evidence of autoimmune diseases usually ascribed to the thyrogastric cluster. Five expressed HLA antigens associated with increased risk for both diabetes and rheumatoid arthritis in adults. Evidence of B cell hyperactivity and impaired T cell response was found in some, but immunoregulatory, function was normal in all. The association of these two diseases may be the result of factors other than chance alone, and may be more common than previously suspected.",

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note = "Funding Information: From the Departments of Pediatrics and Internal Medicine, Yale University School of Medicine. Supported in part by a grant (A1 11785) to Dr. Dwyer from the National Institutes of Health; clinical studies were performed in the Children's Clinical Research Center, supported by a grant (RR-125) from the General Clinical Research Centers Program, Division of Research Resources, National Institutes of Health. *Reprint address: Department of Pediatrics, Yale University School of Medicine, P. O. Box3333, New Haven, CT 06510. **Recipient of a Clinical Investigator A ward, AM 60021, from the National Institutes of Health. ***Investigator for the Howard Hughes Medical Institute.",

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AU - Genel, Myron

AU - Tamborlane, William V.

AU - Dwyer, John M.

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Juvenile rheumatoid arthritis in children with diabetes mellitus

Abstract

Bibliographical note

Funding

UN SDGs

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