Abstract
Purpose: African Americans who shed JC polyomavirus (JCV) in their urine have reduced rates of nondiabetic chronic kidney disease (CKD). We assessed the associations between urinary JCV and urine BK polyomavirus (BKV) with CKD in African Americans with diabetes mellitus. Methods: African Americans with diabetic kidney disease (DKD) and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative PCR. Of the 335 individuals tested, 148 had DKD and 187 were controls. Results: JCV viruria was detected more often in the controls than in the patients with DKD (FIND: 46.6% vs 32.2%; OR, 0.52; 95% CI, 0.29 to 0.93; P = 0.03; AA-DHS: 30.4% vs 26.2%; OR, 0.63; 95% CI, 0.27 to 1.48; P = 0.29). A joint analysis adjusted for age, sex, and study revealed that JC viruria was inversely associated with DKD (OR, 0.56; 95% CI, 0.35 to 0.91; P = 0.02). Statistically significant relationships between BKV and DKD were not observed. Main Conclusions: The results from the present study extend the inverse association between urine JCV and nondiabetic nephropathy in African Americans to DKD. These results imply that common pathways likely involving the innate immune system mediate coincident chronic kidney injury and restriction of JCV replication. Future studies are needed to explore causative pathways and characterize whether the absence of JC viruria can serve as a biomarker for DKD in the African American population.
| Original language | English |
|---|---|
| Pages (from-to) | 2286-2294 |
| Number of pages | 9 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 104 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1 Jun 2019 |
Bibliographical note
Funding Information:We acknowledge the support provided by the Israel Science Foundation, an academic research grant from GlaxoSmithKline, the Ernest and Bonnie Beutler Research Grant Program in
Funding Information:
The FIND study was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases and in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. The present study was supported by the Israel Science Foundation (grant 182/15), an academic research grant from GlaxoSmithKline, the Ernest and Bonnie Beutler Research Grant Program in Genomic Medicine, and the Kaylie Kidney Research Center of Excellence at Rambam. This research was also supported by the US-Israel Binational Science Foundation Proposal (grant 2013504 to B.I.F. and K.L.S.) and the National Institutes of Health (grants U01 DK57298 to B.I.F. and R01 DK084149 to B.I.F.).
Funding Information:
Financial Support: The FIND study was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases and in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. The present study was supported by the Israel Science Foundation (grant 182/15), an academic research grant from GlaxoSmithKline, the Ernest and Bonnie Beutler Research Grant Program in Genomic Medicine, and the Kaylie Kidney Research Center of Excellence at Rambam. This research was also supported by the US–Israel Binational Science Foundation Proposal (grant 2013504 to B.I.F. and K.L.S.) and the National Institutes of Health (grants U01 DK57298 to B.I.F. and R01 DK084149 to B.I.F.).
Publisher Copyright:
Copyright © 2019 Endocrine Society
