It's all about the base: stromal cells are central orchestrators of metastasis

Lea Monteran, Yael Zait, Neta Erez

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The tumor microenvironment (TME) is an integral part of tumors and plays a central role in all stages of carcinogenesis and progression. Each organ has a unique and heterogeneous microenvironment, which affects the ability of disseminated cells to grow in the new and sometimes hostile metastatic niche. Resident stromal cells, such as fibroblasts, osteoblasts, and astrocytes, are essential culprits in the modulation of metastatic progression: they transition from being sentinels of tissue integrity to being dysfunctional perpetrators that support metastatic outgrowth. Therefore, better understanding of the complexity of their reciprocal interactions with cancer cells and with other components of the TME is essential to enable the design of novel therapeutic approaches to prevent metastatic relapse.

Original languageEnglish
Pages (from-to)208-229
Number of pages22
JournalTrends in Cancer
Volume10
Issue number3
Early online date9 Dec 2023
DOIs
StatePublished - Mar 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024

Keywords

  • astrocytes
  • fibroblasts
  • metastasis
  • microenvironment
  • osteoblasts
  • stromal cells

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