Abstract
The tumor microenvironment (TME) is an integral part of tumors and plays a central role in all stages of carcinogenesis and progression. Each organ has a unique and heterogeneous microenvironment, which affects the ability of disseminated cells to grow in the new and sometimes hostile metastatic niche. Resident stromal cells, such as fibroblasts, osteoblasts, and astrocytes, are essential culprits in the modulation of metastatic progression: they transition from being sentinels of tissue integrity to being dysfunctional perpetrators that support metastatic outgrowth. Therefore, better understanding of the complexity of their reciprocal interactions with cancer cells and with other components of the TME is essential to enable the design of novel therapeutic approaches to prevent metastatic relapse.
| Original language | English |
|---|---|
| Pages (from-to) | 208-229 |
| Number of pages | 22 |
| Journal | Trends in Cancer |
| Volume | 10 |
| Issue number | 3 |
| Early online date | 9 Dec 2023 |
| DOIs | |
| State | Published - Mar 2024 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2024
Funding
The figures were designed using BioRender. N.E. is supported by funding from the Israel Science Foundation (ISF), the Department of Defense (DoD) Breast Cancer Research Program (BCRP) Breakthrough Award, the Israel Cancer Research Fund (ICRF Project Grant), and the Melanoma Research Alliance (MRA).
| Funders | Funder number |
|---|---|
| U.S. Department of Defense | |
| Israel Cancer Research Fund | |
| Melanoma Research Alliance | |
| Israel Science Foundation |
Keywords
- astrocytes
- fibroblasts
- metastasis
- microenvironment
- osteoblasts
- stromal cells
