Isotope Labeling Study of Retinal Chromophore Fragmentation

Lihi Musbat; Maria Nihamkin; Shany Ytzhak; Amiram Hirshfeld; Noga Friedman; Jonathan M. Dilger; Mordechai Sheves; Yoni Toker

doi:10.1021/acs.jpca.6b02525

Isotope Labeling Study of Retinal Chromophore Fragmentation

Lihi Musbat
, Maria Nihamkin
, Shany Ytzhak
, Amiram Hirshfeld
, Noga Friedman
, Jonathan M. Dilger
, Mordechai Sheves
, Yoni Toker

Department of Physics - at Bar-Ilan University

Bar-Ilan University
Weizmann Institute of Science
Spectrum Warfare Systems Department

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Previous studies have shown that the gas-phase fragmentation of the retinal chromophore after S0-S1 photoexcitation results in a prominent fragment of mass 248 which cannot be explained by the cleavage of any single bond along the polyene chain. It was therefore theorized that the fragmentation mechanism involves a series of isomerizations and cyclization processes, and two mechanisms for these processes were suggested. Here we used isotope labeling MS-MS to provide conclusive support for the fragmentation mechanism suggested by Coughlan et al. (J. Phys. Chem. Lett. 2014, 5, 3195).

Original language	English
Pages (from-to)	2547-2549
Number of pages	3
Journal	Journal of Physical Chemistry A
Volume	120
Issue number	16
DOIs	https://doi.org/10.1021/acs.jpca.6b02525
State	Published - 28 Apr 2016

Bibliographical note

Publisher Copyright:
© 2016 American Chemical Society.

Funding

This research was supported by GIF Research Grant No. I-2370-303.7/2014 and by the Israel Science Foundation.

Funders	Funder number
German-Israeli Foundation for Scientific Research and Development	I-2370-303.7/2014
Israel Science Foundation

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10.1021/acs.jpca.6b02525

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title = "Isotope Labeling Study of Retinal Chromophore Fragmentation",

abstract = "Previous studies have shown that the gas-phase fragmentation of the retinal chromophore after S0-S1 photoexcitation results in a prominent fragment of mass 248 which cannot be explained by the cleavage of any single bond along the polyene chain. It was therefore theorized that the fragmentation mechanism involves a series of isomerizations and cyclization processes, and two mechanisms for these processes were suggested. Here we used isotope labeling MS-MS to provide conclusive support for the fragmentation mechanism suggested by Coughlan et al. (J. Phys. Chem. Lett. 2014, 5, 3195).",

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AU - Nihamkin, Maria

AU - Ytzhak, Shany

AU - Hirshfeld, Amiram

AU - Friedman, Noga

AU - Dilger, Jonathan M.

AU - Sheves, Mordechai

AU - Toker, Yoni

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Isotope Labeling Study of Retinal Chromophore Fragmentation

Abstract

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