Isothermal titration calorimetry for chiral chemistry

Liora Werber, Yitzhak Mastai

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


One of the most powerful techniques that are currently available to measure thermodynamic parameters such as enthalpy (ΔH), Gibbs free energy (ΔG), entropy changes (ΔS), and binding affinity in chemical reactions is isothermal titration calorimetry (ITC). Recent advances in instrumentation have facilitated the development of ITC as a very essential analytical tool in biology and chemistry. In this article, we will focus on a review of the literature on the application of ITC for the study of chiral systems and chiral interactions. We present studies in which the ITC technique is used to study chiral interactions, for instance in chiral solutions, chiral organometallic complexes, guest-host chiral binding interactions, and biological macromolecules. Finally, we put strong emphasis on the most recent application of ITC for the study of chirality in nanosystems and at the nanoscale.

Original languageEnglish
Pages (from-to)619-631
Number of pages13
Issue number5
StatePublished - May 2018

Bibliographical note

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.


We thank Teva Pharmaceuticals for the Analytical Chemistry Phd scholarship and the Bar‐Ilan President's Phd Scholarship Foundation for financial support.

FundersFunder number
Teva Pharmaceuticals


    • chiral interactions
    • chiral nanoparticles
    • chiral surfaces
    • isothermal titration calorimetry (ITC)
    • microcalorimetry


    Dive into the research topics of 'Isothermal titration calorimetry for chiral chemistry'. Together they form a unique fingerprint.

    Cite this