Abstract
Several recent studies have hypothesized that sense-antisense RNA-transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. We studied human and mouse genomic antisense regions and found that the editing level in these areas is negligible. This observation questions the scope of sense-antisense duplexes formation in-vivo, which is the basis for several proposed regulatory mechanisms.
Original language | English |
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Pages (from-to) | 544-547 |
Number of pages | 4 |
Journal | Trends in Genetics |
Volume | 21 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2005 |
Externally published | Yes |
Bibliographical note
Funding Information:R.S. was supported by a fellowship from the Clore Israel Foundation. E.E. was supported by an Alon Fellowship at Tel Aviv University.