Several recent studies have hypothesized that sense-antisense RNA-transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. We studied human and mouse genomic antisense regions and found that the editing level in these areas is negligible. This observation questions the scope of sense-antisense duplexes formation in-vivo, which is the basis for several proposed regulatory mechanisms.
Bibliographical noteFunding Information:
R.S. was supported by a fellowship from the Clore Israel Foundation. E.E. was supported by an Alon Fellowship at Tel Aviv University.