Abstract
Several recent studies have hypothesized that sense-antisense RNA-transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. We studied human and mouse genomic antisense regions and found that the editing level in these areas is negligible. This observation questions the scope of sense-antisense duplexes formation in-vivo, which is the basis for several proposed regulatory mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 544-547 |
| Number of pages | 4 |
| Journal | Trends in Genetics |
| Volume | 21 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2005 |
| Externally published | Yes |
Bibliographical note
Funding Information:R.S. was supported by a fellowship from the Clore Israel Foundation. E.E. was supported by an Alon Fellowship at Tel Aviv University.