TY - JOUR
T1 - Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection
AU - Youni, Johnny S.
AU - Abassi, Zaid
AU - Skorecki, Karl
N1 - Publisher Copyright:
© 2020 American Physiological Society. All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - The viral pandemic of the coronavirus disease 2019 (COVID-19), generated by a novel mutated severe acute respiratory syndrome coronavirus (SARSCoV- 2), has become a serious worldwide public health emergency, evolving exponentially. While the main organ targeted in this disease is the lungs, other vital organs, such as the heart and kidney, may be implicated. The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the reninangiotensin- aldosterone system (RAAS). The ACE2 is also involved in testicular male regulation of steroidogenesis and spermatogenesis. As the SARS-CoV-2 may have the potential to infect the testis via ACE2 and adversely affect male reproductive system, it is essential to commence with targeted studies to learn from the current pandemic, with the possibility of preemptive intervention, depending on the findings and time course of the continuing pandemic.
AB - The viral pandemic of the coronavirus disease 2019 (COVID-19), generated by a novel mutated severe acute respiratory syndrome coronavirus (SARSCoV- 2), has become a serious worldwide public health emergency, evolving exponentially. While the main organ targeted in this disease is the lungs, other vital organs, such as the heart and kidney, may be implicated. The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the reninangiotensin- aldosterone system (RAAS). The ACE2 is also involved in testicular male regulation of steroidogenesis and spermatogenesis. As the SARS-CoV-2 may have the potential to infect the testis via ACE2 and adversely affect male reproductive system, it is essential to commence with targeted studies to learn from the current pandemic, with the possibility of preemptive intervention, depending on the findings and time course of the continuing pandemic.
UR - http://www.scopus.com/inward/record.url?scp=85085904803&partnerID=8YFLogxK
U2 - 10.1152/AJPENDO.00183.2020
DO - 10.1152/AJPENDO.00183.2020
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C2 - 32421367
AN - SCOPUS:85085904803
SN - 0193-1849
VL - 318
SP - E878-E880
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
IS - 6
ER -
