Is the coexistence of mutations in the genes of factor V and MTHFR a predisposing factor for massive skin necrosis due to loxoscelism?

Y. Mandel; Grotto i; Gdalevich m; D Mimouni; I Ashkenazi; J Haviv; O Shpilberg

Is the coexistence of mutations in the genes of factor V and MTHFR a predisposing factor for massive skin necrosis due to loxoscelism?

Y. Mandel, Grotto i, Gdalevich m, D Mimouni, I Ashkenazi, J Haviv, O Shpilberg

School of Optometry and Vision Science

Research output: Contribution to journal › Article › peer-review

Abstract

A 28-year-old previously healthy man was diagnosed as having an extensive necrotic lesion of his calf due to loxoscelism. One year later he was diagnosed as having co-inheritance of mutations in factor V and methyl tetrahydrofolate reductase (MTHFR). This is the first report of a possible etiologic connection between loxoscelism necrotic lesions and thrombogenic diseases.

Original language	American English
Pages (from-to)	265-270
Journal	Public Health Reviews
Volume	26
Issue number	3
State	Published - 1997

Bibliographical note

Medical Corps, Israel Defense Forces, Israel

Cite this

@article{c3b06eeeab5942478fbdd8bcbda894f9,

title = "Is the coexistence of mutations in the genes of factor V and MTHFR a predisposing factor for massive skin necrosis due to loxoscelism?",

abstract = "A 28-year-old previously healthy man was diagnosed as having an extensive necrotic lesion of his calf due to loxoscelism. One year later he was diagnosed as having co-inheritance of mutations in factor V and methyl tetrahydrofolate reductase (MTHFR). This is the first report of a possible etiologic connection between loxoscelism necrotic lesions and thrombogenic diseases.",

author = "Y. Mandel and Grotto i and Gdalevich m and D Mimouni and I Ashkenazi and J Haviv and O Shpilberg",

note = "Medical Corps, Israel Defense Forces, Israel",

year = "1997",

language = "American English",

volume = "26",

pages = "265--270",

journal = "Public Health Reviews",

issn = "0301-0422",