Irradiation of Arbitrary Time Dependence: Damped-Oscillator Model of Organism's Response

Yehoshua Socol; Yair Y. Shaki; Ludwik Dobrzynski

doi:10.1109/trpms.2020.3042720

Irradiation of Arbitrary Time Dependence: Damped-Oscillator Model of Organism's Response

Yehoshua Socol, Yair Y. Shaki, Ludwik Dobrzynski

Research output: Contribution to journal › Article › peer-review

Abstract

There is evidence from experimental, ecological, and epidemiological studies that low doses of ionizing radiation may be beneficial to human health by causing an adaptive response. A quantitative phenomenological model has been reported earlier, where the time-evolution response to gamma radiation was modeled like the time evolution of a damped oscillator. The model predicted that an organism's resistance to radiation stress can be considerably improved by 'radiation training' - preirradiation. Here, we report an improved more realistic model, taking into account not only the radiation dose rate but also the total radiation dose. The model, if verified by future experiments, might be used to considerably improve the efficacy of radiation therapy by enabling increased therapeutic doses.

Original language	English
Pages (from-to)	475-481
Number of pages	7
Journal	IEEE Transactions on Radiation and Plasma Medical Sciences
Volume	6
Issue number	4
DOIs	https://doi.org/10.1109/trpms.2020.3042720
State	Published - 1 Apr 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 IEEE.

Keywords

Adaptive protection
cancer
fractionation
hormesis
radiation therapy (RT)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/trpms.2020.3042720

Cite this

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Irradiation of Arbitrary Time Dependence: Damped-Oscillator Model of Organism's Response

Abstract

Bibliographical note

Keywords

UN SDGs

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