Iron status and neurobehavioral development of premature infants

Rinat Armony-Sivan; Arthur I. Eidelman; Amos Lanir; Devora Sredni; Shlomo Yehuda

doi:10.1038/sj.jp.7211178

Iron status and neurobehavioral development of premature infants

Rinat Armony-Sivan
, Arthur I. Eidelman
, Amos Lanir
, Devora Sredni
, Shlomo Yehuda

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Objective: This study was conducted to examine the relation between iron status and neurobehavioral development in premature infants. Study Design: Infants born before 34 weeks postmenstrual age and who were medically stable were studied. Anemia was defined as hemoglobin ≤ 10 g/Dl and low iron stores as a serum ferritin concentration ≤75 μ g/l. The infants were classified as anemic with low ferritin (Group 1; n = 18), anemic with normal ferritin (Group 2; n = 14), and nonanemic with normal ferritin (Group 3; n = 21). A total of 18 reflexes were behaviorally evaluated at 37 weeks postmenstrual age and "reflex scores" were compared between the groups. Higher scores reflect a greater percentage of abnormal reflexes. Results: Infants in group 1 (anemia/low ferritin) had a significantly higher reflex score (51.45±18.32%) than infants in Group 3 (38.32±17.7596). Group 2 had an intermediate score (45.40± 21.70%), but not different from the other two groups. Conclusion: These data indicate that low iron status, both measured by anemia and ferritin levels, is related to poorer neurobehavioral status in premature infants.

Original language	English
Pages (from-to)	757-762
Number of pages	6
Journal	Journal of Perinatology
Volume	24
Issue number	12
DOIs	https://doi.org/10.1038/sj.jp.7211178
State	Published - Dec 2004

Bibliographical note

Funding Information:
Department of Pediatrics (R.A.-S., A.I.E.), Shaare-Zedek Medical Center, Jerusalem, Israel; Hebrew University School of Medicine (A.I.E.), Jerusalem; Biochemistry Department (A.L.), Bnai-Zion Medical Center, Haifa, Israel; The Interdisciplinary Department of Social Sciences (D.S.), Bar-Ilan University, Ramat Gan, Israel; and Department of Psychology (S.Y.), Bar-Ilan University, Ramat Gan, Israel Supported in part by the Irving Harris Early Development Educational Program of the Shaare-Zedek Medical Center, Jerusalem, Israel.

Funding

Department of Pediatrics (R.A.-S., A.I.E.), Shaare-Zedek Medical Center, Jerusalem, Israel; Hebrew University School of Medicine (A.I.E.), Jerusalem; Biochemistry Department (A.L.), Bnai-Zion Medical Center, Haifa, Israel; The Interdisciplinary Department of Social Sciences (D.S.), Bar-Ilan University, Ramat Gan, Israel; and Department of Psychology (S.Y.), Bar-Ilan University, Ramat Gan, Israel Supported in part by the Irving Harris Early Development Educational Program of the Shaare-Zedek Medical Center, Jerusalem, Israel.

Funders
Biochemistry Department
Bnai-Zion Medical Center, Haifa, Israel
Hebrew University School of Medicine
Interdisciplinary Department of Social Sciences
Shaare-Zedek Medical Center
Department of Psychology, Western Washington University
Bar-Ilan University

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10.1038/sj.jp.7211178

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title = "Iron status and neurobehavioral development of premature infants",

abstract = "Objective: This study was conducted to examine the relation between iron status and neurobehavioral development in premature infants. Study Design: Infants born before 34 weeks postmenstrual age and who were medically stable were studied. Anemia was defined as hemoglobin ≤ 10 g/Dl and low iron stores as a serum ferritin concentration ≤75 μ g/l. The infants were classified as anemic with low ferritin (Group 1; n = 18), anemic with normal ferritin (Group 2; n = 14), and nonanemic with normal ferritin (Group 3; n = 21). A total of 18 reflexes were behaviorally evaluated at 37 weeks postmenstrual age and {"}reflex scores{"} were compared between the groups. Higher scores reflect a greater percentage of abnormal reflexes. Results: Infants in group 1 (anemia/low ferritin) had a significantly higher reflex score (51.45±18.32\%) than infants in Group 3 (38.32±17.7596). Group 2 had an intermediate score (45.40± 21.70\%), but not different from the other two groups. Conclusion: These data indicate that low iron status, both measured by anemia and ferritin levels, is related to poorer neurobehavioral status in premature infants.",

author = "Rinat Armony-Sivan and Eidelman, \{Arthur I.\} and Amos Lanir and Devora Sredni and Shlomo Yehuda",

note = "Funding Information: Department of Pediatrics (R.A.-S., A.I.E.), Shaare-Zedek Medical Center, Jerusalem, Israel; Hebrew University School of Medicine (A.I.E.), Jerusalem; Biochemistry Department (A.L.), Bnai-Zion Medical Center, Haifa, Israel; The Interdisciplinary Department of Social Sciences (D.S.), Bar-Ilan University, Ramat Gan, Israel; and Department of Psychology (S.Y.), Bar-Ilan University, Ramat Gan, Israel Supported in part by the Irving Harris Early Development Educational Program of the Shaare-Zedek Medical Center, Jerusalem, Israel.",

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AU - Armony-Sivan, Rinat

AU - Eidelman, Arthur I.

AU - Lanir, Amos

AU - Sredni, Devora

AU - Yehuda, Shlomo

N1 - Funding Information: Department of Pediatrics (R.A.-S., A.I.E.), Shaare-Zedek Medical Center, Jerusalem, Israel; Hebrew University School of Medicine (A.I.E.), Jerusalem; Biochemistry Department (A.L.), Bnai-Zion Medical Center, Haifa, Israel; The Interdisciplinary Department of Social Sciences (D.S.), Bar-Ilan University, Ramat Gan, Israel; and Department of Psychology (S.Y.), Bar-Ilan University, Ramat Gan, Israel Supported in part by the Irving Harris Early Development Educational Program of the Shaare-Zedek Medical Center, Jerusalem, Israel.

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N2 - Objective: This study was conducted to examine the relation between iron status and neurobehavioral development in premature infants. Study Design: Infants born before 34 weeks postmenstrual age and who were medically stable were studied. Anemia was defined as hemoglobin ≤ 10 g/Dl and low iron stores as a serum ferritin concentration ≤75 μ g/l. The infants were classified as anemic with low ferritin (Group 1; n = 18), anemic with normal ferritin (Group 2; n = 14), and nonanemic with normal ferritin (Group 3; n = 21). A total of 18 reflexes were behaviorally evaluated at 37 weeks postmenstrual age and "reflex scores" were compared between the groups. Higher scores reflect a greater percentage of abnormal reflexes. Results: Infants in group 1 (anemia/low ferritin) had a significantly higher reflex score (51.45±18.32%) than infants in Group 3 (38.32±17.7596). Group 2 had an intermediate score (45.40± 21.70%), but not different from the other two groups. Conclusion: These data indicate that low iron status, both measured by anemia and ferritin levels, is related to poorer neurobehavioral status in premature infants.

AB - Objective: This study was conducted to examine the relation between iron status and neurobehavioral development in premature infants. Study Design: Infants born before 34 weeks postmenstrual age and who were medically stable were studied. Anemia was defined as hemoglobin ≤ 10 g/Dl and low iron stores as a serum ferritin concentration ≤75 μ g/l. The infants were classified as anemic with low ferritin (Group 1; n = 18), anemic with normal ferritin (Group 2; n = 14), and nonanemic with normal ferritin (Group 3; n = 21). A total of 18 reflexes were behaviorally evaluated at 37 weeks postmenstrual age and "reflex scores" were compared between the groups. Higher scores reflect a greater percentage of abnormal reflexes. Results: Infants in group 1 (anemia/low ferritin) had a significantly higher reflex score (51.45±18.32%) than infants in Group 3 (38.32±17.7596). Group 2 had an intermediate score (45.40± 21.70%), but not different from the other two groups. Conclusion: These data indicate that low iron status, both measured by anemia and ferritin levels, is related to poorer neurobehavioral status in premature infants.

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Iron status and neurobehavioral development of premature infants

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