Abstract
The natural iron chelator deferoxamine was bonded to agarose-polyacrolein microsphere beads (APAMB). This novel deferoxamine-conjugated APAMB (DCA), when used as the sorbent in a plasnu/haemoperfusion system, showed specific and rapid removal of iron from plasma and blood in vitro; in vivo experiments also showed specific iron removal. The advantages of this sorbent are minimal damage to biocompounds during haemoperfusion, high capacity and specificity to iron, and the possibility of reuse.
| Original language | English |
|---|---|
| Pages (from-to) | 9-16 |
| Number of pages | 8 |
| Journal | Biomaterials |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1985 |
| Externally published | Yes |
Keywords
- Deferoxamine
- haemoperfusion
- iron chelation
- iron overload
- polyacrolein microspheres
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