Iron detoxification by haemoperfusion through deferoxamine-conjugated agarose-polyacrolein microsphere beads

David Horowitz; Shlomo Margel; Tuvia Shimoni

doi:10.1016/0142-9612(85)90031-6

Iron detoxification by haemoperfusion through deferoxamine-conjugated agarose-polyacrolein microsphere beads

David Horowitz, Shlomo Margel, Tuvia Shimoni

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The natural iron chelator deferoxamine was bonded to agarose-polyacrolein microsphere beads (APAMB). This novel deferoxamine-conjugated APAMB (DCA), when used as the sorbent in a plasnu/haemoperfusion system, showed specific and rapid removal of iron from plasma and blood in vitro; in vivo experiments also showed specific iron removal. The advantages of this sorbent are minimal damage to biocompounds during haemoperfusion, high capacity and specificity to iron, and the possibility of reuse.

Original language	English
Pages (from-to)	9-16
Number of pages	8
Journal	Biomaterials
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/0142-9612(85)90031-6
State	Published - Jan 1985
Externally published	Yes

Keywords

Deferoxamine
haemoperfusion
iron chelation
iron overload
polyacrolein microspheres

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10.1016/0142-9612(85)90031-6

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abstract = "The natural iron chelator deferoxamine was bonded to agarose-polyacrolein microsphere beads (APAMB). This novel deferoxamine-conjugated APAMB (DCA), when used as the sorbent in a plasnu/haemoperfusion system, showed specific and rapid removal of iron from plasma and blood in vitro; in vivo experiments also showed specific iron removal. The advantages of this sorbent are minimal damage to biocompounds during haemoperfusion, high capacity and specificity to iron, and the possibility of reuse.",

keywords = "Deferoxamine, haemoperfusion, iron chelation, iron overload, polyacrolein microspheres",

author = "David Horowitz and Shlomo Margel and Tuvia Shimoni",

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N2 - The natural iron chelator deferoxamine was bonded to agarose-polyacrolein microsphere beads (APAMB). This novel deferoxamine-conjugated APAMB (DCA), when used as the sorbent in a plasnu/haemoperfusion system, showed specific and rapid removal of iron from plasma and blood in vitro; in vivo experiments also showed specific iron removal. The advantages of this sorbent are minimal damage to biocompounds during haemoperfusion, high capacity and specificity to iron, and the possibility of reuse.

AB - The natural iron chelator deferoxamine was bonded to agarose-polyacrolein microsphere beads (APAMB). This novel deferoxamine-conjugated APAMB (DCA), when used as the sorbent in a plasnu/haemoperfusion system, showed specific and rapid removal of iron from plasma and blood in vitro; in vivo experiments also showed specific iron removal. The advantages of this sorbent are minimal damage to biocompounds during haemoperfusion, high capacity and specificity to iron, and the possibility of reuse.

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KW - iron chelation

KW - iron overload

KW - polyacrolein microspheres

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Iron detoxification by haemoperfusion through deferoxamine-conjugated agarose-polyacrolein microsphere beads

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Keywords

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