Iron deficiency induces reversal of dopamine dependent circadian cycles: Differential response to d-amphetamine and TRH

Moussa B.H. Youdim; Shlomo Yehuda

doi:10.1016/0196-9781(85)90313-4

Iron deficiency induces reversal of dopamine dependent circadian cycles: Differential response to d-amphetamine and TRH

Moussa B.H. Youdim, Shlomo Yehuda

Department of Psychology

Technion-Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Rats made nutritionally iron-deficient (ID) have significantly diminished haemoglobin, serum iron and hypothermic response to d-amphetamine (15 mg/kg). The reduction of d-amphetamine induced hypothermia is comparatively greater in the dark than in the light period. Neither TRH (1 mg/kg) nor CG 3703, a peptidase resistent TRH analogue (1 mg/kg), induced hypothermia in control of ID animals. However, in combination with d-amphetamine, TRH and CG 3703 did not alter the hypothermic effect observed initially with d-amphetamine. In contrast to control animals, ID rats treated with saline or d-amphetamine (15 mg/kg) exhibited a greater degree of motor activity in the light as compared to the dark period. However, the overall activity (light plus dark) was unchanged in the ID group. The motor activity in response to TRH or CG 3703 was not changed as a result of iron-deficiency. These differential responses may be due to a more pronounced action of d-amphetamine on dopaminergic system, which is known to be changed in iron-deficiency, and of TRH and CG 3703 on the noradrenergic neurones.

Original language	English
Pages (from-to)	851-855
Number of pages	5
Journal	Peptides
Volume	6
Issue number	5
DOIs	https://doi.org/10.1016/0196-9781(85)90313-4
State	Published - 1985

Bibliographical note

Funding Information:
We thank Smith, Kline and French (U.S.A.) for a generous donation of d-amphetamine-sulphate; Chemie Gruenthal GmbH (Germany) for a generous supply of TRH and CG 3703. The support of Bar-Ban University Research Authority and the Sapir Foundation and the Rappaport Family Institute for Research in the Medical Sciences is gratefully acknowledged.

Funding

We thank Smith, Kline and French (U.S.A.) for a generous donation of d-amphetamine-sulphate; Chemie Gruenthal GmbH (Germany) for a generous supply of TRH and CG 3703. The support of Bar-Ban University Research Authority and the Sapir Foundation and the Rappaport Family Institute for Research in the Medical Sciences is gratefully acknowledged.

Funders
Bar-Ban University Research Authority
Rappaport Family Institute for Research in the Medical Sciences
Sapir Foundation

Keywords

Dopamine
Iron-deficiency
Locomotor activity
Noradrenaline
TRH and CG 3703
Thermoregulation
d-Amphetamine

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10.1016/0196-9781(85)90313-4

Cite this

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title = "Iron deficiency induces reversal of dopamine dependent circadian cycles: Differential response to d-amphetamine and TRH",

abstract = "Rats made nutritionally iron-deficient (ID) have significantly diminished haemoglobin, serum iron and hypothermic response to d-amphetamine (15 mg/kg). The reduction of d-amphetamine induced hypothermia is comparatively greater in the dark than in the light period. Neither TRH (1 mg/kg) nor CG 3703, a peptidase resistent TRH analogue (1 mg/kg), induced hypothermia in control of ID animals. However, in combination with d-amphetamine, TRH and CG 3703 did not alter the hypothermic effect observed initially with d-amphetamine. In contrast to control animals, ID rats treated with saline or d-amphetamine (15 mg/kg) exhibited a greater degree of motor activity in the light as compared to the dark period. However, the overall activity (light plus dark) was unchanged in the ID group. The motor activity in response to TRH or CG 3703 was not changed as a result of iron-deficiency. These differential responses may be due to a more pronounced action of d-amphetamine on dopaminergic system, which is known to be changed in iron-deficiency, and of TRH and CG 3703 on the noradrenergic neurones.",

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note = "Funding Information: We thank Smith, Kline and French (U.S.A.) for a generous donation of d-amphetamine-sulphate; Chemie Gruenthal GmbH (Germany) for a generous supply of TRH and CG 3703. The support of Bar-Ban University Research Authority and the Sapir Foundation and the Rappaport Family Institute for Research in the Medical Sciences is gratefully acknowledged.",

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Iron deficiency induces reversal of dopamine dependent circadian cycles: Differential response to d-amphetamine and TRH

Abstract

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Keywords

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