Iron deficiency-induced circadian rhythm reversal of dopaminergic-mediated behaviours and thermoregulation in rats

Moussa B.H. Youdim, Shlomo Yehuda, Yehuda Ben-Uriah

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Abstract

An iron-free diet for 28 days caused a reduced level of iron in the blood. Iron deficient rats exhibited a lower level of motor activity and reversed circadian rhytms of thermoregulation and motor activity. The hypothermic effect of d-amphetamine was significantly reduced in iron deficient rats, and the magnitude of this effect was correlated with the decrease in iron in the blood and brain. The hypermotility effect of d-amphetamine was also significantly reduced. Apomorphine-induced stereotyped behaviour was greater during the light period in contrast to that of control rats. The results of this study indicate that iron plays a major role in the normal function of the monoaminergic system in the brain, particularly in the dopaminergic system, via modification of dopaminergic receptors.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalEuropean Journal of Pharmacology
Volume74
Issue number4
DOIs
StatePublished - 24 Sep 1981

Bibliographical note

Funding Information:
This work was supported by a grant from the Ministry of Health (Jerusalem) to M.B.H.Y. d-Amphetamine sulfate was generously donated by Smith, Kline and French, U.S.A.

Keywords

  • Dopamine receptor
  • Hypothermia
  • Iron dificiency d-Amphetamine
  • Motor activity
  • Reversed circadian rhythm
  • Stereotyped behaviour

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