An iron-free diet for 28 days caused a reduced level of iron in the blood. Iron deficient rats exhibited a lower level of motor activity and reversed circadian rhytms of thermoregulation and motor activity. The hypothermic effect of d-amphetamine was significantly reduced in iron deficient rats, and the magnitude of this effect was correlated with the decrease in iron in the blood and brain. The hypermotility effect of d-amphetamine was also significantly reduced. Apomorphine-induced stereotyped behaviour was greater during the light period in contrast to that of control rats. The results of this study indicate that iron plays a major role in the normal function of the monoaminergic system in the brain, particularly in the dopaminergic system, via modification of dopaminergic receptors.
Bibliographical noteFunding Information:
This work was supported by a grant from the Ministry of Health (Jerusalem) to M.B.H.Y. d-Amphetamine sulfate was generously donated by Smith, Kline and French, U.S.A.
- Dopamine receptor
- Iron dificiency d-Amphetamine
- Motor activity
- Reversed circadian rhythm
- Stereotyped behaviour