Iron deficiency (ID) at both birth and 9 months predicts right frontal EEG asymmetry in infancy

Rinat Armony-Sivan, Bingquan Zhu, Katy M. Clark, Blair Richards, Chai Ji, Niko Kaciroti, Jie Shao, Betsy Lozoff

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

This study considered effects of timing and duration of iron deficiency (ID) on frontal EEG asymmetry in infancy. In healthy term Chinese infants, EEG was recorded at 9 months in three experimental conditions: baseline, peek-a-boo, and stranger approach. Eighty infants provided data for all conditions. Prenatal ID was defined as low cord ferritin or high ZPP/H. Postnatal ID was defined as ≥ two abnormal iron measures at 9 months. Study groups were pre- and postnatal ID, prenatal ID only, postnatal ID only, and not ID. GLM repeated measure analysis showed a main effect for iron group. The pre- and postnatal ID group had negative asymmetry scores, reflecting right frontal EEG asymmetry (mean±SE: -.18±.07) versus prenatal ID only (.00±.04), postnatal ID only (.03±.04), and not ID (.02±.04). Thus, ID at both birth and 9 months was associated with right frontal EEG asymmetry, a neural correlate of behavioral withdrawal and negative emotions.

Original languageEnglish
Pages (from-to)462-470
Number of pages9
JournalDevelopmental Psychobiology
Volume58
Issue number4
DOIs
StatePublished - 1 May 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Wiley Periodicals, Inc.

Keywords

  • EEG
  • Emotion
  • Iron deficiency
  • Pre- and postnatal

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