Iron biofortified carioca bean (phaseolus vulgaris L.)—based brazilian diet delivers more absorbable iron and affects the gut microbiota in vivo (gallus gallus)

Desirrê Morais Dias, Nikolai Kolba, Dana Binyamin, Oren Ziv, Marilia Regini Nutti, Hércia Stampini Duarte Martino, Raymond P. Glahn, Omry Koren, Elad Tako

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Biofortification aims to improve the micronutrient concentration and bioavailability in staple food crops. Unlike other strategies utilized to alleviate Fe deficiency, studies of the gut microbiota in the context of Fe biofortification are scarce. In this study, we performed a 6-week feeding trial in Gallus gallus (n = 15), aimed to investigate the Fe status and the alterations in the gut microbiome following the administration of Fe-biofortified carioca bean based diet (BC) versus a Fe-standard carioca bean based diet (SC). The tested diets were designed based on the Brazilian food consumption survey. Two primary outcomes were observed: (1) a significant increase in total body Hb-Fe values in the group receiving the Fe-biofortified carioca bean based diet; and (2) changes in the gut microbiome composition and function were observed, specifically, significant changes in phylogenetic diversity between treatment groups, as there was increased abundance of bacteria linked to phenolic catabolism, and increased abundance of beneficial SCFA-producing bacteria in the BC group. The BC group also presented a higher intestinal villi height compared to the SC group. Our results demonstrate that the Fe-biofortified carioca bean variety was able to moderately improve Fe status and to positively affect the intestinal functionality and bacterial populations.

Original languageEnglish
Article number1970
JournalNutrients
Volume10
Issue number12
DOIs
StatePublished - 13 Dec 2018

Bibliographical note

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Funding

Acknowledgments: The authors would like to thank the Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil) for the Doctor’s fellowship.

FundersFunder number
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

    Keywords

    • Biofortification
    • Gut microbiome
    • Intestinal morphometry
    • Iron deficiency
    • Metagenome
    • Polyphenols

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