Ionic Waves Propagation Along the Dendritic Cytoskeleton as a Signaling Mechanism

Avner Priel, Jack A. Tuszynski, Horacio F. Cantiello

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Scopus citations


We outline the physical conditions that enable cytoskeletal polymers, such as actin filaments (AFs) and microtubules, to act as electrical transmission lines for ion flows along their lengths. For AFs we propose a model in which each protein subunit is an electric element with a capacitive, inductive, and resistive property due to the molecular structure of the filament and viscosity of the solution. Based on the conductivity rules that apply to electrical circuits, we discuss the properties of ionic waves that propagate along actin filaments. We then discuss the dynamics of C-termini states in microtubules and their networks, including the interactions with ions and signal transmission via microtubule-associated proteins. Experiments on ionic conductivity along AFs and microtubules validate the basic assumptions postulated in our models. As a consequence of these results we propose a new signaling mechanism in the cell, especially in neurons, that involves clouds of ions surrounding protein filaments which may travel without significant decay along the axon or the dendritic tree. These signals may be utilized to control various membrane properties, for example, the transition rate of ion channel opening and closing, local membrane conductivity, and vesicle trafficking.

Original languageEnglish
Title of host publicationAspects of the Cytoskeleton
EditorsEdward Bittar, Seema Khurana
Number of pages18
StatePublished - 2006
Externally publishedYes

Publication series

NameAdvances in Molecular and Cell Biology
ISSN (Print)1569-2558

Bibliographical note

Funding Information:
JT and AP were supported by grants from MITACS, NSERC, and the Allard Foundation. Additional funding from Technological Innovations, LLC of Rochester, NY is gratefully acknowledged.


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