Abstract
In order to study the impact of chemical modifications of lipopolyamines on their gene delivery properties, we have introduced cyclic guanidines into the polyamine moiety. These lipopolyamino-cycloguanidines can be easily obtained by reacting polyamines with 2-methylmercapto-2-imidazolinium iodide or 2-methylmercapto tetrahydropyrimidinium iodide. These lipopolyamino- cycloguanidines constitute a novel family of cationic lipids. (C) 2000 Elsevier Science Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 675-679 |
| Number of pages | 5 |
| Journal | Tetrahedron Letters |
| Volume | 41 |
| Issue number | 5 |
| DOIs | |
| State | Published - 29 Jan 2000 |
Bibliographical note
Funding Information:This work was supported by Rhône-Poulenc Rorer and the Centre National de la Recherche Scientifique CNRS. Dr. Gerardo Byk is indebted to Arc-En-Ciel program 1999 and the Marcus Center for Pharmaceutical and Medicinal Chemistry for supporting this collaboration. We thank Dr. Marc Vuilhorgne and his staff from the Structural Analysis Department of Rhône-Poulenc Rorer.
Funding
This work was supported by Rhône-Poulenc Rorer and the Centre National de la Recherche Scientifique CNRS. Dr. Gerardo Byk is indebted to Arc-En-Ciel program 1999 and the Marcus Center for Pharmaceutical and Medicinal Chemistry for supporting this collaboration. We thank Dr. Marc Vuilhorgne and his staff from the Structural Analysis Department of Rhône-Poulenc Rorer.
| Funders |
|---|
| Centre National de la Recherche Scientifique CNRS |
| Rhône-Poulenc Rorer |
Keywords
- Cationic lipid
- Cyclic guanidine
- Gene delivery
- Polyamine
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