Introducing a methyl group into pyridines and quinolines: A mini-review

Eliezer Falb, Alfred Hassner

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Pyridines are ubiquitous N-heterocycles that are present in many natural products and synthetic drugs with important biological applications. Introduction into a pyridine of a methyl (Me) or an isotopically labeled methyl group at carbon can alter its biological properties. However, regioselective introduction of a Me group in high yield, and preferably in a green manner, is often quite challenging. In this mini-review, several methods, most of which are recent, are examined whereby a Me or CD3 is introduced at a specific carbon in pyridines, as well as in some quinolines.

Original languageEnglish
Pages (from-to)766-813
Number of pages48
JournalHeterocycles
Volume99
Issue number2
DOIs
StatePublished - 2019

Bibliographical note

Publisher Copyright:
© 2019 The Japan Institute of Heterocyclic Chemistry.

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