TY - JOUR
T1 - Introducing a methyl group into pyridines and quinolines
T2 - A mini-review
AU - Falb, Eliezer
AU - Hassner, Alfred
N1 - Publisher Copyright:
© 2019 The Japan Institute of Heterocyclic Chemistry.
PY - 2019
Y1 - 2019
N2 - Pyridines are ubiquitous N-heterocycles that are present in many natural products and synthetic drugs with important biological applications. Introduction into a pyridine of a methyl (Me) or an isotopically labeled methyl group at carbon can alter its biological properties. However, regioselective introduction of a Me group in high yield, and preferably in a green manner, is often quite challenging. In this mini-review, several methods, most of which are recent, are examined whereby a Me or CD3 is introduced at a specific carbon in pyridines, as well as in some quinolines.
AB - Pyridines are ubiquitous N-heterocycles that are present in many natural products and synthetic drugs with important biological applications. Introduction into a pyridine of a methyl (Me) or an isotopically labeled methyl group at carbon can alter its biological properties. However, regioselective introduction of a Me group in high yield, and preferably in a green manner, is often quite challenging. In this mini-review, several methods, most of which are recent, are examined whereby a Me or CD3 is introduced at a specific carbon in pyridines, as well as in some quinolines.
UR - http://www.scopus.com/inward/record.url?scp=85069696419&partnerID=8YFLogxK
U2 - 10.3987/REV-18-SR(F)6
DO - 10.3987/REV-18-SR(F)6
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AN - SCOPUS:85069696419
SN - 0385-5414
VL - 99
SP - 766
EP - 813
JO - Heterocycles
JF - Heterocycles
IS - 2
ER -