Intrinsically Disordered Synthetic Polymers in Biomedical Applications

Elif Yuce-Erarslan, Abraham (Avi) J. Domb, Haytam Kasem, Vladimir N. Uversky, Orkid Coskuner-Weber

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

In biology and medicine, intrinsically disordered synthetic polymers bio-mimicking intrinsically disordered proteins, which lack stable three-dimensional structures, possess high structural/conformational flexibility. They are prone to self-organization and can be extremely useful in various biomedical applications. Among such applications, intrinsically disordered synthetic polymers can have potential usage in drug delivery, organ transplantation, artificial organ design, and immune compatibility. The designing of new syntheses and characterization mechanisms is currently required to provide the lacking intrinsically disordered synthetic polymers for biomedical applications bio-mimicked using intrinsically disordered proteins. Here, we present our strategies for designing intrinsically disordered synthetic polymers for biomedical applications based on bio-mimicking intrinsically disordered proteins.

Original languageEnglish
Article number2406
JournalPolymers
Volume15
Issue number10
DOIs
StatePublished - 22 May 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • artificial organs
  • bioinspired polymers
  • drug delivery
  • immune compatibility
  • intrinsically disordered polymers
  • organ transplantation

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