TY - JOUR
T1 - Intrinsically Disordered Synthetic Polymers in Biomedical Applications
AU - Yuce-Erarslan, Elif
AU - Domb, Abraham (Avi) J.
AU - Kasem, Haytam
AU - Uversky, Vladimir N.
AU - Coskuner-Weber, Orkid
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/5/22
Y1 - 2023/5/22
N2 - In biology and medicine, intrinsically disordered synthetic polymers bio-mimicking intrinsically disordered proteins, which lack stable three-dimensional structures, possess high structural/conformational flexibility. They are prone to self-organization and can be extremely useful in various biomedical applications. Among such applications, intrinsically disordered synthetic polymers can have potential usage in drug delivery, organ transplantation, artificial organ design, and immune compatibility. The designing of new syntheses and characterization mechanisms is currently required to provide the lacking intrinsically disordered synthetic polymers for biomedical applications bio-mimicked using intrinsically disordered proteins. Here, we present our strategies for designing intrinsically disordered synthetic polymers for biomedical applications based on bio-mimicking intrinsically disordered proteins.
AB - In biology and medicine, intrinsically disordered synthetic polymers bio-mimicking intrinsically disordered proteins, which lack stable three-dimensional structures, possess high structural/conformational flexibility. They are prone to self-organization and can be extremely useful in various biomedical applications. Among such applications, intrinsically disordered synthetic polymers can have potential usage in drug delivery, organ transplantation, artificial organ design, and immune compatibility. The designing of new syntheses and characterization mechanisms is currently required to provide the lacking intrinsically disordered synthetic polymers for biomedical applications bio-mimicked using intrinsically disordered proteins. Here, we present our strategies for designing intrinsically disordered synthetic polymers for biomedical applications based on bio-mimicking intrinsically disordered proteins.
KW - artificial organs
KW - bioinspired polymers
KW - drug delivery
KW - immune compatibility
KW - intrinsically disordered polymers
KW - organ transplantation
UR - http://www.scopus.com/inward/record.url?scp=85160613179&partnerID=8YFLogxK
U2 - 10.3390/polym15102406
DO - 10.3390/polym15102406
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 37242981
AN - SCOPUS:85160613179
SN - 2073-4360
VL - 15
JO - Polymers
JF - Polymers
IS - 10
M1 - 2406
ER -