Intrinsically disordered proteins at the nano-scale

T. Ehm; H. Shinar; S. Meir; A. Sekhon; V. Sethi; I. L. Morgan; G. Rahamim; O. A. Saleh; R. Beck

doi:10.1088/2399-1984/abfb7c

Intrinsically disordered proteins at the nano-scale

T. Ehm, H. Shinar, S. Meir, A. Sekhon, V. Sethi, I. L. Morgan, G. Rahamim, O. A. Saleh, R. Beck

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The human proteome is enriched in proteins that do not fold into a stable 3D structure. These intrinsically disordered proteins (IDPs) spontaneously fluctuate between a large number of configurations in their native form. Remarkably, the disorder does not lead to dysfunction as with denatured folded proteins. In fact, unlike denatured proteins, recent evidence strongly suggests that multiple biological functions stem from such structural plasticity. Here, focusing on the nanometer length-scale, we review the latest advances in IDP research and discuss some of the future directions in this highly promising field.

Original language	English
Article number	022501
Journal	Nano Futures
Volume	5
Issue number	2
DOIs	https://doi.org/10.1088/2399-1984/abfb7c
State	Published - 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 IOP Publishing Ltd.

Funding

This work was supported by the National Science Foundation under Grant No. 1715627, the United States-Israel Bi-national Science Foundation under Grant No. 2016696, and the Israel Science Foundation under Grant Nos. 1454/19.

Funders	Funder number
United States–Israel Bi-National Science Foundation	2016696
National Science Foundation
Directorate for Biological Sciences	1715627
Israel Science Foundation	1454/19

Keywords

FRET
Intrinsically disordered proteins
NMR FCS
Nanoscopic characterization
SAXS
Single-molecule force spectroscopy

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AU - Sethi, V.

AU - Morgan, I. L.

AU - Rahamim, G.

AU - Saleh, O. A.

AU - Beck, R.

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KW - Intrinsically disordered proteins

KW - NMR FCS

KW - Nanoscopic characterization

KW - SAXS

KW - Single-molecule force spectroscopy

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Intrinsically disordered proteins at the nano-scale

Abstract

Bibliographical note

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Keywords

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