Intraventricular hemorrhage in preterm infants: Coagulation perspectives

Amir A. Kuperman, Gili Kenet, Emmanuel Papadakis, Benjamin Brenner

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


It has long been considered that a severe coagulation deficiency in premature newborns could be a major contributing factor in the occurrence of intraventricular hemorrhage (IVH). High-grade IVH has also been shown to coincide with severe derangement of coagulation in extremely low birth weight infants. This review focuses on the relevance of the physiologically developing immature hemostatic system to IVH, and the potential benefit of agents affecting hemostasis for IVH therapy or prevention in preterm infants. The findings of small, open-label interventional studies on the effect of ethamsylate, vitamin K, fresh frozen plasma, recombinant activated factor VII, and prothrombin complex concentrate on the premature coagulation system will be reviewed.

Original languageEnglish
Pages (from-to)730-736
Number of pages7
JournalSeminars in Thrombosis and Hemostasis
Issue number7
StatePublished - 2011
Externally publishedYes


  • Intraventricular hemorrhage
  • prematurity
  • recombinant factor VIIa
  • thrombin
  • vitamin K


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