TY - JOUR
T1 - Intravenous immunoglobulin for treatment of toxic epidermal necrolysis
AU - Nasser, Maher
AU - Bitterman-Deutsch, Ora
AU - Nassar, Faris
PY - 2005/2
Y1 - 2005/2
N2 - We report three female patients suffering from toxic epidermal necrolysis, with 30% to 70% epidermal detachment. Alleged causative agents were dipyrone, dibenzazepine, and allopurinol. All patients were treated by intravenous immunoglobulins (IVIG) and survived without further complications, although poor prognostic factors such as concomitant diabetes, large areas of epidermal detachment, and pancytopenia were present. We report these cases with emphasis on the concept that prompt diagnosis, withdrawal of causative drugs, and immediate treatment are imperative for the favorable outcome of the disease. Our patients can be added to the list of those patients who were successfully treated by IVIG, as indicated in this review of the literature.
AB - We report three female patients suffering from toxic epidermal necrolysis, with 30% to 70% epidermal detachment. Alleged causative agents were dipyrone, dibenzazepine, and allopurinol. All patients were treated by intravenous immunoglobulins (IVIG) and survived without further complications, although poor prognostic factors such as concomitant diabetes, large areas of epidermal detachment, and pancytopenia were present. We report these cases with emphasis on the concept that prompt diagnosis, withdrawal of causative drugs, and immediate treatment are imperative for the favorable outcome of the disease. Our patients can be added to the list of those patients who were successfully treated by IVIG, as indicated in this review of the literature.
KW - Intravenous immunoglobulin
KW - Toxic epidermal necrolysis
UR - http://www.scopus.com/inward/record.url?scp=13844267551&partnerID=8YFLogxK
U2 - 10.1097/00000441-200502000-00007
DO - 10.1097/00000441-200502000-00007
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C2 - 15711426
AN - SCOPUS:13844267551
SN - 0002-9629
VL - 329
SP - 95
EP - 98
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 2
ER -