Intracellular trafficking and dynamics of P bodies.

Adva Aizer, Yaron Shav-Tal

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

RNAs are exported from the nucleus to the cytoplasm, where they undergo translation and produce proteins needed for the cellular life cycle. Some mRNAs are targeted by different RNA decay mechanisms and thereby undergo degradation. The 5'-->3' degradation machinery localizes to cytoplasmic complexes termed P bodies (PBs). They function in RNA turnover, translational repression, RNA-mediated silencing, and RNA storage. A quantitative live-cell imaging approach to study the dynamic aspects of PB trafficking in the cytoplasm revealed that PB movements are rather confined and dependent on an existing microtubule network. Microtubule depolymerization led to a drastic decrease in PB mobility, as well as a release of regulation on PB assembly and a dramatic increase in PB numbers. The different aspects of PB trafficking and encounters with mRNA molecules in the cytoplasm are discussed.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalPrion
Volume2
Issue number4
DOIs
StatePublished - Oct 2008

Bibliographical note

Funding Information:
Y.S.T. thanks the following agencies for their support: the Israel Science Foundation, the German-Israeli Foundation, DIP, the USA-Israel Binational Science Foundation, the Israel Cancer Research Fund, the Ministries of Health & Science, and the Israel Cancer Association. Y.S.T. thanks the Israel Science Foundation for the equipment grant for the fluorescence live-cell imaging microscope. Y.S.T. is the Jane Stern Lebell Family Fellow in Life Sciences at Bar-Ilan University.

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