Interplays of different types of epitranscriptomic mRNA modifications

Praveenkumar Rengaraj; Aleš Obrdlík; Dragana Vukić; Nandan Mysore Varadarajan; Liam P. Keegan; Štěpánka Vaňáčová; Mary A. O’Connell

doi:10.1080/15476286.2021.1969113

Interplays of different types of epitranscriptomic mRNA modifications

Praveenkumar Rengaraj, Aleš Obrdlík, Dragana Vukić, Nandan Mysore Varadarajan, Liam P. Keegan, Štěpánka Vaňáčová, Mary A. O’Connell

Masaryk University

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m⁶A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m⁶Am, m⁵C, m¹A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.

Original language	English
Pages (from-to)	19-30
Number of pages	12
Journal	RNA Biology
Volume	18
Issue number	S1
DOIs	https://doi.org/10.1080/15476286.2021.1969113
State	Published - 15 Oct 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Funding

This paper was based upon work from COST Action CA16120 EPITRAN, supported by COST (European Cooperation in Science and Technology)“ and Ministry of Education, Youth and Sports within programme INTER-COST (LTC18052).(MOC and SV).

Funders	Funder number
INTER-COST	LTC18052
European Cooperation in Science and Technology
Ministerstvo Školství, Mládeže a Tělovýchovy

Keywords

ADAR
Inosine
epitranscriptome
mA
mC
pseudouridine

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10.1080/15476286.2021.1969113

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title = "Interplays of different types of epitranscriptomic mRNA modifications",

abstract = "Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m6A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m6Am, m5C, m1A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.",

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note = "Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2021",

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doi = "10.1080/15476286.2021.1969113",

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AU - Rengaraj, Praveenkumar

AU - Obrdlík, Aleš

AU - Vukić, Dragana

AU - Varadarajan, Nandan Mysore

AU - Keegan, Liam P.

AU - Vaňáčová, Štěpánka

AU - O’Connell, Mary A.

PY - 2021/10/15

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N2 - Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m6A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m6Am, m5C, m1A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.

AB - Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m6A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m6Am, m5C, m1A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.

KW - ADAR

KW - Inosine

KW - epitranscriptome

KW - mA

KW - mC

KW - pseudouridine

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Interplays of different types of epitranscriptomic mRNA modifications

Abstract

Bibliographical note

Funding

Keywords

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