Interplays of different types of epitranscriptomic mRNA modifications

Praveenkumar Rengaraj; Aleš Obrdlík; Dragana Vukić; Nandan Mysore Varadarajan; Liam P. Keegan; Štěpánka Vaňáčová; Mary A. O’Connell

doi:10.1080/15476286.2021.1969113

Interplays of different types of epitranscriptomic mRNA modifications

Praveenkumar Rengaraj, Aleš Obrdlík, Dragana Vukić, Nandan Mysore Varadarajan, Liam P. Keegan, Štěpánka Vaňáčová, Mary A. O’Connell

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m⁶A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m⁶Am, m⁵C, m¹A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.

Original language	English
Pages (from-to)	19-30
Number of pages	12
Journal	RNA Biology
Volume	18
Issue number	S1
DOIs	https://doi.org/10.1080/15476286.2021.1969113
State	Published - 2021
Externally published	Yes

Bibliographical note

Funding Information:
This paper was based upon work from COST Action CA16120 EPITRAN, supported by COST (European Cooperation in Science and Technology)“ and Ministry of Education, Youth and Sports within programme INTER-COST (LTC18052).(MOC and SV).

Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

ADAR
Inosine
epitranscriptome
mA
mC
pseudouridine

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10.1080/15476286.2021.1969113

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title = "Interplays of different types of epitranscriptomic mRNA modifications",

abstract = "Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m6A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m6Am, m5C, m1A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.",

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year = "2021",

doi = "10.1080/15476286.2021.1969113",

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AU - Rengaraj, Praveenkumar

AU - Obrdlík, Aleš

AU - Vukić, Dragana

AU - Varadarajan, Nandan Mysore

AU - Keegan, Liam P.

AU - Vaňáčová, Štěpánka

AU - O’Connell, Mary A.

PY - 2021

Y1 - 2021

N2 - Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m6A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m6Am, m5C, m1A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.

AB - Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m6A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m6Am, m5C, m1A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.

KW - ADAR

KW - Inosine

KW - epitranscriptome

KW - mA

KW - mC

KW - pseudouridine

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JO - RNA Biology

JF - RNA Biology

IS - S1

ER -

Interplays of different types of epitranscriptomic mRNA modifications

Abstract

Bibliographical note

Keywords

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