Interplays of different types of epitranscriptomic mRNA modifications

Praveenkumar Rengaraj, Aleš Obrdlík, Dragana Vukić, Nandan Mysore Varadarajan, Liam P. Keegan, Štěpánka Vaňáčová, Mary A. O’Connell

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m6A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m6Am, m5C, m1A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.

Original languageEnglish
Pages (from-to)19-30
Number of pages12
JournalRNA Biology
Volume18
Issue numberS1
DOIs
StatePublished - 15 Oct 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • ADAR
  • Inosine
  • epitranscriptome
  • mA
  • mC
  • pseudouridine

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