Interleukin-4 modulates the proliferation and differentiation of glial cells

Chaya Brodie, Nurit Goldreich

    Research output: Contribution to journalArticlepeer-review

    23 Scopus citations


    We examined the effects of the T cell-derived cytokine, interleukin (IL)-4 on the proliferation and differentiation of C6 glial cells. IL-4 exerted a biphasic effect on cell proliferation, increasing cell proliferation at concentrations ranging from 10 to 50 ng/ml and inhibiting at higher concentrations. Inhibition of cell proliferation was associated with differentiation of the cells to express astrocytic phenotypes as evidenced by morphology, increased glial fibrially acidic protein (GFAP) immunoreactivity and elevated glutamine synthetase expression. IL-4 also inductd the secretion of nerve growth factor by these cells. These results suggest an important role for IL-4 during instances of CNS trauma and inflammation.

    Original languageEnglish
    Pages (from-to)91-97
    Number of pages7
    JournalJournal of Neuroimmunology
    Issue number1
    StatePublished - Nov 1994

    Bibliographical note

    Funding Information:
    We wish to thank Mrs. Avrille Goldreich for the skillful preparation of the manuscript. This work has been supported in part by the Harvett-Aviv Fund for Neuroscience Research.


    • Glia
    • Glial fibrillary acidic protein
    • Glutamine synthetase
    • Interleukin-4
    • Nerve growth factor


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