Interleukin-4 modulates the proliferation and differentiation of glial cells

Chaya Brodie; Nurit Goldreich

doi:10.1016/0165-5728(94)90150-3

Interleukin-4 modulates the proliferation and differentiation of glial cells

Chaya Brodie, Nurit Goldreich

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We examined the effects of the T cell-derived cytokine, interleukin (IL)-4 on the proliferation and differentiation of C6 glial cells. IL-4 exerted a biphasic effect on cell proliferation, increasing cell proliferation at concentrations ranging from 10 to 50 ng/ml and inhibiting at higher concentrations. Inhibition of cell proliferation was associated with differentiation of the cells to express astrocytic phenotypes as evidenced by morphology, increased glial fibrially acidic protein (GFAP) immunoreactivity and elevated glutamine synthetase expression. IL-4 also inductd the secretion of nerve growth factor by these cells. These results suggest an important role for IL-4 during instances of CNS trauma and inflammation.

Original language	English
Pages (from-to)	91-97
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/0165-5728(94)90150-3
State	Published - Nov 1994

Bibliographical note

Funding Information:
We wish to thank Mrs. Avrille Goldreich for the skillful preparation of the manuscript. This work has been supported in part by the Harvett-Aviv Fund for Neuroscience Research.

Funding

We wish to thank Mrs. Avrille Goldreich for the skillful preparation of the manuscript. This work has been supported in part by the Harvett-Aviv Fund for Neuroscience Research.

Funders	Funder number
Ryder Briggs Neuroscience Research Fund

Keywords

Glia
Glial fibrillary acidic protein
Glutamine synthetase
Interleukin-4
Nerve growth factor

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10.1016/0165-5728(94)90150-3

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title = "Interleukin-4 modulates the proliferation and differentiation of glial cells",

abstract = "We examined the effects of the T cell-derived cytokine, interleukin (IL)-4 on the proliferation and differentiation of C6 glial cells. IL-4 exerted a biphasic effect on cell proliferation, increasing cell proliferation at concentrations ranging from 10 to 50 ng/ml and inhibiting at higher concentrations. Inhibition of cell proliferation was associated with differentiation of the cells to express astrocytic phenotypes as evidenced by morphology, increased glial fibrially acidic protein (GFAP) immunoreactivity and elevated glutamine synthetase expression. IL-4 also inductd the secretion of nerve growth factor by these cells. These results suggest an important role for IL-4 during instances of CNS trauma and inflammation.",

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author = "Chaya Brodie and Nurit Goldreich",

note = "Funding Information: We wish to thank Mrs. Avrille Goldreich for the skillful preparation of the manuscript. This work has been supported in part by the Harvett-Aviv Fund for Neuroscience Research.",

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AU - Goldreich, Nurit

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Interleukin-4 modulates the proliferation and differentiation of glial cells

Abstract

Bibliographical note

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Keywords

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