Abstract
Human interleukin-3-like activity (IL-3-LA), a factor possessing similar characteristics to interleukin-3 and having clony stimulating factor (CSF) activity, has recently been defined. In the present study, IL-3-LA levels in the sera of women before and after delivery were examined. The results indicate a significant increase in IL-3-LA levels in women before delivery as compared to IL-3-LA levels after delivery or to non-pregnant healthy women. The ability of mononuclear cells from women before and after delivery to produce IL-3-LA was similar to that of mononuclear cells from cord blood. In addition, the effect of progesterone on in vitro IL-3-LA production was examined and a stimulatory dose-dependent effect was observed. These observations point to the hypothesis that during pregnancy IL-3-LA levels are modulated by progesterone. With placental loss, the IL-3-LA in the sera decreases, although the mononuclear cells previously affected by the hormone continue to produce cytokines.
Original language | English |
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Pages (from-to) | 211-216 |
Number of pages | 6 |
Journal | Journal of Reproductive Immunology |
Volume | 22 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1992 |
Bibliographical note
Funding Information:This work was supported by a grant of the Chief Scientist Ministry of Health, Israel and the Frieda Stollman Chair in Cancer Research.
Funding
This work was supported by a grant of the Chief Scientist Ministry of Health, Israel and the Frieda Stollman Chair in Cancer Research.
Funders | Funder number |
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Chief Scientist Ministry of Health, Israel |
Keywords
- human pregnancy
- interleukin-3-like activity
- progesterone