TY - JOUR
T1 - Interleukin-3-like activity levels in pregnant women
T2 - possible modulation by progesterone
AU - Fishman, P.
AU - Shoenfeld, Y.
AU - Hart, J.
AU - Zigelman, R.
AU - Shamir, Y.
AU - Feldberg, D.
AU - Inbar, O.
AU - Sredni, D.
AU - Djaldetti, M.
N1 - Funding Information:
This work was supported by a grant of the Chief Scientist Ministry of Health, Israel and the Frieda Stollman Chair in Cancer Research.
PY - 1992/8
Y1 - 1992/8
N2 - Human interleukin-3-like activity (IL-3-LA), a factor possessing similar characteristics to interleukin-3 and having clony stimulating factor (CSF) activity, has recently been defined. In the present study, IL-3-LA levels in the sera of women before and after delivery were examined. The results indicate a significant increase in IL-3-LA levels in women before delivery as compared to IL-3-LA levels after delivery or to non-pregnant healthy women. The ability of mononuclear cells from women before and after delivery to produce IL-3-LA was similar to that of mononuclear cells from cord blood. In addition, the effect of progesterone on in vitro IL-3-LA production was examined and a stimulatory dose-dependent effect was observed. These observations point to the hypothesis that during pregnancy IL-3-LA levels are modulated by progesterone. With placental loss, the IL-3-LA in the sera decreases, although the mononuclear cells previously affected by the hormone continue to produce cytokines.
AB - Human interleukin-3-like activity (IL-3-LA), a factor possessing similar characteristics to interleukin-3 and having clony stimulating factor (CSF) activity, has recently been defined. In the present study, IL-3-LA levels in the sera of women before and after delivery were examined. The results indicate a significant increase in IL-3-LA levels in women before delivery as compared to IL-3-LA levels after delivery or to non-pregnant healthy women. The ability of mononuclear cells from women before and after delivery to produce IL-3-LA was similar to that of mononuclear cells from cord blood. In addition, the effect of progesterone on in vitro IL-3-LA production was examined and a stimulatory dose-dependent effect was observed. These observations point to the hypothesis that during pregnancy IL-3-LA levels are modulated by progesterone. With placental loss, the IL-3-LA in the sera decreases, although the mononuclear cells previously affected by the hormone continue to produce cytokines.
KW - human pregnancy
KW - interleukin-3-like activity
KW - progesterone
UR - http://www.scopus.com/inward/record.url?scp=0026623396&partnerID=8YFLogxK
U2 - 10.1016/0165-0378(92)90017-X
DO - 10.1016/0165-0378(92)90017-X
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C2 - 1501207
AN - SCOPUS:0026623396
SN - 0165-0378
VL - 22
SP - 211
EP - 216
JO - Journal of Reproductive Immunology
JF - Journal of Reproductive Immunology
IS - 2
ER -
