Interleukin-3-like activity levels in pregnant women: possible modulation by progesterone

P. Fishman, Y. Shoenfeld, J. Hart, R. Zigelman, Y. Shamir, D. Feldberg, O. Inbar, D. Sredni, M. Djaldetti

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8 Scopus citations


Human interleukin-3-like activity (IL-3-LA), a factor possessing similar characteristics to interleukin-3 and having clony stimulating factor (CSF) activity, has recently been defined. In the present study, IL-3-LA levels in the sera of women before and after delivery were examined. The results indicate a significant increase in IL-3-LA levels in women before delivery as compared to IL-3-LA levels after delivery or to non-pregnant healthy women. The ability of mononuclear cells from women before and after delivery to produce IL-3-LA was similar to that of mononuclear cells from cord blood. In addition, the effect of progesterone on in vitro IL-3-LA production was examined and a stimulatory dose-dependent effect was observed. These observations point to the hypothesis that during pregnancy IL-3-LA levels are modulated by progesterone. With placental loss, the IL-3-LA in the sera decreases, although the mononuclear cells previously affected by the hormone continue to produce cytokines.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalJournal of Reproductive Immunology
Issue number2
StatePublished - Aug 1992

Bibliographical note

Funding Information:
This work was supported by a grant of the Chief Scientist Ministry of Health, Israel and the Frieda Stollman Chair in Cancer Research.


  • human pregnancy
  • interleukin-3-like activity
  • progesterone


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