Interfacing the Cell with “Biomimetic Membrane Proteins”

Asaf Grupi; Idan Ashur; Nurit Degani-Katzav; Shimon Yudovich; Zehavit Shapira; Adan Marzouq; Lion Morgenstein; Yossi Mandel; Shimon Weiss

doi:10.1002/smll.201903006

Interfacing the Cell with “Biomimetic Membrane Proteins”

Asaf Grupi, Idan Ashur, Nurit Degani-Katzav, Shimon Yudovich, Zehavit Shapira, Adan Marzouq, Lion Morgenstein, Yossi Mandel, Shimon Weiss

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Integral membrane proteins mediate a myriad of cellular processes and are the target of many therapeutic drugs. Enhancement and extension of the functional scope of membrane proteins can be realized by membrane incorporation of engineered nanoparticles designed for specific diagnostic and therapeutic applications. In contrast to hydrophobic insertion of small amphiphilic molecules, delivery and membrane incorporation of particles on the nanometric scale poses a crucial barrier for technological development. In this perspective, the transformative potential of biomimetic membrane proteins (BMPs), current state of the art, and the barriers that need to be overcome in order to advance the field are discussed.

Original language	English
Article number	1903006
Journal	Small
Volume	15
Issue number	52
DOIs	https://doi.org/10.1002/smll.201903006
State	Published - 1 Dec 2019

Bibliographical note

Publisher Copyright:
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Funding

The authors thank Drs. Jack Li, Yung Kuo, Eugene Stulz, and Volodymyr Shvadchak for extremely helpful discussions. This work has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No. 669941, by the Human Frontier Science Program (HFSP) research grant RGP0061/2015, by the BER program of the Department of Energy Office of Science grant DE-FC03-02ER63421, and by the STROBE National Science Foundation Science & Technology Center, Grant No. DMR-1548924.

Funders	Funder number
Department of Energy Office of Science	DE-FC03-02ER63421
European Union's Horizon 2020 research and innovation program
STROBE National Science Foundation Science & Technology Center	DMR-1548924
Human Frontier Science Program	RGP0061/2015
Horizon 2020 Framework Programme	669941
European Commission

Keywords

biomimetic membrane proteins
membrane proteins
nanoparticles insertion into membranes
nanorods
quantum dots

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10.1002/smll.201903006

Cite this

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Interfacing the Cell with “Biomimetic Membrane Proteins”

Abstract

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Keywords

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