Interfacing the Cell with “Biomimetic Membrane Proteins”

Asaf Grupi, Idan Ashur, Nurit Degani-Katzav, Shimon Yudovich, Zehavit Shapira, Adan Marzouq, Lion Morgenstein, Yossi Mandel, Shimon Weiss

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Integral membrane proteins mediate a myriad of cellular processes and are the target of many therapeutic drugs. Enhancement and extension of the functional scope of membrane proteins can be realized by membrane incorporation of engineered nanoparticles designed for specific diagnostic and therapeutic applications. In contrast to hydrophobic insertion of small amphiphilic molecules, delivery and membrane incorporation of particles on the nanometric scale poses a crucial barrier for technological development. In this perspective, the transformative potential of biomimetic membrane proteins (BMPs), current state of the art, and the barriers that need to be overcome in order to advance the field are discussed.

Original languageEnglish
Article number1903006
JournalSmall
Volume15
Issue number52
DOIs
StatePublished - 1 Dec 2019

Bibliographical note

Publisher Copyright:
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • biomimetic membrane proteins
  • membrane proteins
  • nanoparticles insertion into membranes
  • nanorods
  • quantum dots

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