Interaction of MIF-I or alpha-MSH with D-amphetamine or chlorpromazine on thermoregulation and motor activity of rats maintained at different ambient temperatures

Shlomo Yehuda, Abba J. Kastin

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Administration of several doses of MIF-I or alpha-MSH did not modify colonic temperature or the level of motor activity of rats in ambient temperatures of 4° or 20°C. However, the thermoregulatory but not motor effects of the interaction between MIF-I or alpha-MSH with d-amphetamine were dependent upon ambient temperature. At 4°C, 1.0 mg/kg of both peptides enhanced the d-amphetamine-induced hypothermia, but at 20°C both peptides blocked the hyperthermic effects of d-amphetamine. The hypothermic effect of chlorpromazine (CPZ) at 4°C and 20°C was blocked by 1.0 mg/kg MIF-I but not by 1.0 mg/kg alpha-MSH. No linear dose response relationships between various doses of MIF-I or alpha-MSH and thermal responses were found. Administration of melanin or the use of hypophysectomized rats did not alter the significant interactions observed after peripheral injections.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalPeptides
Volume1
Issue number3
DOIs
StatePublished - 1980
Externally publishedYes

Bibliographical note

Funding Information:
Supported in part by the Medical Research Service of the Veterans Administration, NIH (NS 07664), and The American Parkinson Disease Foundation. The authors appreciate the help of Debra B. Lazarus in typing the manuscript.

Keywords

  • Ambient temperature
  • Amphetamine
  • Drug interaction
  • Locomotion
  • Peptides
  • Phenothiazines
  • Thermoregulation

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