Interaction of epidermal growth factor with vasoac11ve hormones in the regulation of phospholipase a2

N. Hack; B. Margolis; J. Schlessinger; K. Skorecki

doi:10.1515/jbcpp.1991.2.3.161

Interaction of epidermal growth factor with vasoac11ve hormones in the regulation of phospholipase a2

N. Hack, B. Margolis, J. Schlessinger, K. Skorecki

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The interaction of growth factors with their receptors initiates a series of intracellular events that are of critical importance in the control of normal cell proliferation. In this regard considerable attention has focused on the coupling of phopholipase C-_ϒto growth factor receptor tyrosine kinases. In contrast, the interaction of growth factors with phospholipase A₂has received less attention, most likely because the arachidonic acid release response has been considered to be an accompaniment of phospholipase C activation. Work from our laboratory using a well defined model system demonstrated a distinct coupling relationship of epidermal growth factor to phospholipase A₂. This review focuses on the interaction of the epidermal growth factor receptor with phospholipases involved in both mitogenic and non-mitogenic responses and discusses their possible relation with vasoactive hormones.

Original language	English
Pages (from-to)	161-182
Number of pages	22
Journal	Journal of Basic and Clinical Physiology and Pharmacology
Volume	2
Issue number	3
DOIs	https://doi.org/10.1515/jbcpp.1991.2.3.161
State	Published - Jul 1991
Externally published	Yes

Bibliographical note

Funding Information:
N.H. is a recipient of a Chisholm Memorial Fellowship. B.M. is a Lucille P. Markey Scholar. This work was supported by grants from the Kidney Foundation of Canada, and the Heart and Stroke Foundation of Ontario to K.L.S. The technical assistance of P. dayman and W. Zeng is gratefully appreciated as is the secretarial assistance of V. Brown.

Funding

N.H. is a recipient of a Chisholm Memorial Fellowship. B.M. is a Lucille P. Markey Scholar. This work was supported by grants from the Kidney Foundation of Canada, and the Heart and Stroke Foundation of Ontario to K.L.S. The technical assistance of P. dayman and W. Zeng is gratefully appreciated as is the secretarial assistance of V. Brown.

Funders	Funder number
Kidney Foundation of Canada
Heart and Stroke Foundation of Canada

Keywords

G-proteins
arachidonic acid
mesangial cells
phospholipase C-y
tyrosine kinase

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10.1515/jbcpp.1991.2.3.161

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abstract = "The interaction of growth factors with their receptors initiates a series of intracellular events that are of critical importance in the control of normal cell proliferation. In this regard considerable attention has focused on the coupling of phopholipase C-ϒto growth factor receptor tyrosine kinases. In contrast, the interaction of growth factors with phospholipase A2has received less attention, most likely because the arachidonic acid release response has been considered to be an accompaniment of phospholipase C activation. Work from our laboratory using a well defined model system demonstrated a distinct coupling relationship of epidermal growth factor to phospholipase A2. This review focuses on the interaction of the epidermal growth factor receptor with phospholipases involved in both mitogenic and non-mitogenic responses and discusses their possible relation with vasoactive hormones.",

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AB - The interaction of growth factors with their receptors initiates a series of intracellular events that are of critical importance in the control of normal cell proliferation. In this regard considerable attention has focused on the coupling of phopholipase C-ϒto growth factor receptor tyrosine kinases. In contrast, the interaction of growth factors with phospholipase A2has received less attention, most likely because the arachidonic acid release response has been considered to be an accompaniment of phospholipase C activation. Work from our laboratory using a well defined model system demonstrated a distinct coupling relationship of epidermal growth factor to phospholipase A2. This review focuses on the interaction of the epidermal growth factor receptor with phospholipases involved in both mitogenic and non-mitogenic responses and discusses their possible relation with vasoactive hormones.

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Interaction of epidermal growth factor with vasoac11ve hormones in the regulation of phospholipase a2

Abstract

Bibliographical note

Funding

Keywords

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