Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier

Oshra Betzer; Malka Shilo; Menachem Motiei; Rachela Popovtzer

doi:10.1117/12.2510353

Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier

Oshra Betzer, Malka Shilo, Menachem Motiei, Rachela Popovtzer

Tel Aviv University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

14 Scopus citations

Abstract

A major challenge for treatment of neurodegenerative disorders is the need to overcome the restrictive mechanism of the blood-brain-barrier (BBB) for delivery of therapeutic agents into the brain. Our goal was to develop an efficient nanoparticle-based system with the ability to bypass the BBB by targeting insulin receptors. We demonstrate that insulincoated gold-nanoparticles (INS-GNPs) can serve as an effective endogenous BBB transport system for delivering therapeutics into the brain. We further conducted a quantitative in-vivo investigation of the effect of nanoparticle size (20, 50 and 70nm) on the ability of INS-GNPs to cross the BBB. The most widespread bio-distribution and highest accumulation within the brain (5% of the injected dose) was observed using 20nm INS-GNPs, two hours post-injection. In-vivo CT imaging revealed that particles migrated to specific brain regions, rich in insulin receptors, which are important targets for the treatment of various neurodegenerative disorders. The findings described herein suggest the potential beneficial use of INS-GNPs as nano-vehicles for the transport of drugs through the BBB.

Original language	English
Title of host publication	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI
Editors	Dan V. Nicolau, Ewa M. Goldys, Dror Fixler
Publisher	SPIE
ISBN (Electronic)	9781510624245
DOIs	https://doi.org/10.1117/12.2510353
State	Published - 2019
Event	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI 2019 - San Francisco, United States Duration: 3 Feb 2019 → 4 Feb 2019

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10891
ISSN (Print)	1605-7422

Conference

Conference	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI 2019
Country/Territory	United States
City	San Francisco
Period	3/02/19 → 4/02/19

Bibliographical note

Publisher Copyright:
© 2019 SPIE.

Funding

This work was partially supported by the Council for Higher Education Postdoctoral Fellowship for Outstanding Woman in Science, and by the Ministry of Science Technology & Space Postdoctoral scholarship, granted to Oshra Betzer.

Funders	Funder number
Ministry of Science Technology
Council for Higher Education

Keywords

Blood-brain barrier
CT imaging
Gold nanoparticles
Insulin

Access to Document

10.1117/12.2510353

Cite this

Betzer, O., Shilo, M., Motiei, M., & Popovtzer, R. (2019). Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier. In D. V. Nicolau, E. M. Goldys, & D. Fixler (Eds.), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI Article 108911H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10891). SPIE. https://doi.org/10.1117/12.2510353

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abstract = "A major challenge for treatment of neurodegenerative disorders is the need to overcome the restrictive mechanism of the blood-brain-barrier (BBB) for delivery of therapeutic agents into the brain. Our goal was to develop an efficient nanoparticle-based system with the ability to bypass the BBB by targeting insulin receptors. We demonstrate that insulincoated gold-nanoparticles (INS-GNPs) can serve as an effective endogenous BBB transport system for delivering therapeutics into the brain. We further conducted a quantitative in-vivo investigation of the effect of nanoparticle size (20, 50 and 70nm) on the ability of INS-GNPs to cross the BBB. The most widespread bio-distribution and highest accumulation within the brain (5% of the injected dose) was observed using 20nm INS-GNPs, two hours post-injection. In-vivo CT imaging revealed that particles migrated to specific brain regions, rich in insulin receptors, which are important targets for the treatment of various neurodegenerative disorders. The findings described herein suggest the potential beneficial use of INS-GNPs as nano-vehicles for the transport of drugs through the BBB.",

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Betzer, O, Shilo, M, Motiei, M & Popovtzer, R 2019, Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier. in DV Nicolau, EM Goldys & D Fixler (eds), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI., 108911H, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10891, SPIE, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI 2019, San Francisco, United States, 3/02/19. https://doi.org/10.1117/12.2510353

Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier. / Betzer, Oshra; Shilo, Malka; Motiei, Menachem et al.
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI. ed. / Dan V. Nicolau; Ewa M. Goldys; Dror Fixler. SPIE, 2019. 108911H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10891).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Betzer O, Shilo M, Motiei M, Popovtzer R. Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier. In Nicolau DV, Goldys EM, Fixler D, editors, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI. SPIE. 2019. 108911H. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2510353

Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier

Abstract

Publication series

Conference

Bibliographical note

Funding

Keywords

Access to Document

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