Instability of dinucleotide repeats in Hodgkin's disease

Z. Mark, A. Toren, N. Amariglio, G. Schiby, F. Brok-Simoni, G. Rechavi

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Tumorigenesis has been shown to proceed through a series of genetic alterations involving protooncogenes and tumor suppressor genes. However, the investigation of genomic instability of microsatellites has disclosed a new mechanism for human carcinogenesis, which is involved not only in hereditary nonpolyposis colon cancer (HNPCC) but in a number of other malignancies as well. To determine whether microsatellite instability is involved in Hodgkin's disease, we screened 16 such tumors using 7 microsatellite marker loci on 6 chromosome arms 4, 5, 9p, 9q, 11, 14, and 17. Using the polymerase chain reaction method, DNA samples from the tumors and from normal peripheral blood leukocytes from each patient were compared for the allelic pattern produced at each locus. Five cases of genomic instability were identified, suggesting that this mechanism is relevant to the pathogenesis of HD.

Original languageEnglish
Pages (from-to)148-152
Number of pages5
JournalAmerican Journal of Hematology
Issue number2
StatePublished - Feb 1998
Externally publishedYes


  • Hodgkin's disease
  • Instability
  • Microsatellites


Dive into the research topics of 'Instability of dinucleotide repeats in Hodgkin's disease'. Together they form a unique fingerprint.

Cite this