Insights into the initiation of TCR signaling

Arup K. Chakraborty; Arthur Weiss

doi:10.1038/ni.2940

Insights into the initiation of TCR signaling

Arup K. Chakraborty, Arthur Weiss

Research output: Contribution to journal › Review article › peer-review

274 Scopus citations

Abstract

The initiation of T cell antigen receptor signaling is a key step that can result in T cell activation and the orchestration of an adaptive immune response. Early events in T cell receptor signaling can distinguish between agonist and endogenous ligands with exquisite selectivity, and show extraordinary sensitivity to minute numbers of agonists in a sea of endogenous ligands. We review our current knowledge of models and crucial molecules that aim to provide a mechanistic explanation for these observations. Building on current understanding and a discussion of unresolved issues, we propose a molecular model for initiation of T cell receptor signaling that may serve as a useful guide for future studies.

Original language	English
Pages (from-to)	798-807
Number of pages	10
Journal	Nature Immunology
Volume	15
Issue number	9
DOIs	https://doi.org/10.1038/ni.2940
State	Published - Sep 2014
Externally published	Yes

Bibliographical note

Funding Information:
We thank M. Fruschicheva for help with the references. We also thank K. Vicari of the Nature Publishing Group for her artistic work on the figures in this article. This work was supported, in part, by a grant from the US National Institutes of Health (PO1 AI091580 to A.K.C. and A.W.).

Funding

We thank M. Fruschicheva for help with the references. We also thank K. Vicari of the Nature Publishing Group for her artistic work on the figures in this article. This work was supported, in part, by a grant from the US National Institutes of Health (PO1 AI091580 to A.K.C. and A.W.).

Funders	Funder number
National Institutes of Health
National Institute of Allergy and Infectious Diseases	P01AI091580

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Insights into the initiation of TCR signaling

Abstract

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