Injectable formulations of poly(lactic acid) and its copolymers in clinical use

Anjali Jain, Konda Reddy Kunduru, Arijit Basu, Boaz Mizrahi, Abraham J. Domb, Wahid Khan

Research output: Contribution to journalReview articlepeer-review

127 Scopus citations

Abstract

Poly(lactic acid) and its copolymers have revolutionized the field of drug delivery due to their excellent biocompatibility and tunable physico-chemical properties. These copolymers have served the healthcare sector by contributing many products to combat various diseases and for biomedical applications. This article provides a comprehensive overview of clinically used products of poly(lactic acid) and its copolymers. Multi-dimension information covering product approval, formulation aspects and clinical status is described to provide a panoramic overview of each product. Moreover, leading patented technologies and various clinical trials on these products for different applications are included. This review focuses on marketed injectable formulations of PLA and its copolymers.

Original languageEnglish
Pages (from-to)213-227
Number of pages15
JournalAdvanced Drug Delivery Reviews
Volume107
DOIs
StatePublished - 15 Dec 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.

Keywords

  • Injectable depot
  • Microspheres
  • PLA clinical products
  • PLA copolymers
  • Poly(lactic acid)

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