Abstract
Particulate systems are widely used in biomedical applications, yet current systems are limited by their stability, complicated production processes, and the use of toxic excipients and cosolvents. Here, a new concept for an injectable nanocarrier system based on the in situ self-assembled star polyethylene glycol (PEG)– poly(lactic-co-glycolic acid) (PLGA)/drug mixture is presented. The new injectable material is based on a neat (solvent-free) liquid copolymer that self-assembles after it is injected along with the drug to form a particulate delivery system. The nanocarriers’ formation rate and encapsulation capabilities of hydrophobic drugs can be fine-tuned by changing the molecular weight of the PLGA segment. Furthermore, the starPEG–PLGA-based system demonstrates potential as a drug carrier for hydrophobic drugs and shows biocompatibility with cell line culture.
| Original language | English |
|---|---|
| Article number | 2000069 |
| Journal | Advanced NanoBiomed Research |
| Volume | 1 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2021 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2021 The Authors. Advanced NanoBiomed Research published by Wiley-VCH GmbH.
Funding
The authors thank the Russell Berrie Nanotechnology Institute, Technion, for helping support this research.
| Funders | Funder number |
|---|---|
| Russell Berrie Nanotechnology Institute | |
| Technion-Israel Institute of Technology |
Keywords
- drug delivery
- injectable
- polyethylene glycol
- self-assembly
- star polymers