Injectable Drug Delivery System Based on In Situ Self-Assembly of Liquid Star Polyethylene Glycol–Poly(lactic-co-glycolic acid)

Bat hen Eylon, Alona Shagan, Ayelet Shabtay-Orbach, Adi Gross, Boaz Mizrahi

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Particulate systems are widely used in biomedical applications, yet current systems are limited by their stability, complicated production processes, and the use of toxic excipients and cosolvents. Here, a new concept for an injectable nanocarrier system based on the in situ self-assembled star polyethylene glycol (PEG)– poly(lactic-co-glycolic acid) (PLGA)/drug mixture is presented. The new injectable material is based on a neat (solvent-free) liquid copolymer that self-assembles after it is injected along with the drug to form a particulate delivery system. The nanocarriers’ formation rate and encapsulation capabilities of hydrophobic drugs can be fine-tuned by changing the molecular weight of the PLGA segment. Furthermore, the starPEG–PLGA-based system demonstrates potential as a drug carrier for hydrophobic drugs and shows biocompatibility with cell line culture.

Original languageEnglish
Article number2000069
JournalAdvanced NanoBiomed Research
Volume1
Issue number3
DOIs
StatePublished - Mar 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Advanced NanoBiomed Research published by Wiley-VCH GmbH.

Funding

The authors thank the Russell Berrie Nanotechnology Institute, Technion, for helping support this research.

FundersFunder number
Russell Berrie Nanotechnology Institute
Technion-Israel Institute of Technology

    Keywords

    • drug delivery
    • injectable
    • polyethylene glycol
    • self-assembly
    • star polymers

    Fingerprint

    Dive into the research topics of 'Injectable Drug Delivery System Based on In Situ Self-Assembly of Liquid Star Polyethylene Glycol–Poly(lactic-co-glycolic acid)'. Together they form a unique fingerprint.

    Cite this